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Rothamsted scientists have engineered a plant to produce a range of vital chemicals used in the manufacture of common everyday items, the majority of which are usually obtained from fossil fuels.

The class of chemicals – a group of molecules called 4-VPs (vinyl phenols) - are widely used in the manufacture of products such as food and make up – and even includes a plastic used in television and mobile phone screens.

The breakthrough came when researchers altered a metabolic pathway in the oilseed plant camelina and diverted it to make derivatives of these potentially useful products instead.

This is the first time this has been achieved in plants, and the crop has already been tested successfully in the field – a vital step in producing the volume of chemicals needed by manufacturers.

Using crops to produce the raw materials for industry could reduce our reliance on petrochemicals, which would help the move to net zero, says the study’s lead author, Dr Guillaume Menard.

“It’s amazing just how many everyday products are made from, or contain, chemicals extracted from crude oil and its derivatives. We all know the issues around the continued extraction and use of fossil fuels, but turning camelina plants into ‘green factories’ to make substitutes for these petrochemical compounds is a great sustainable alternative.”

Camelina is an emerging oilseed crop that is increasingly being used to produce a range of speciality food and non-food products in Europe and North America.

Writing in the journal Metabolic Engineering, the researchers explain how they inserted a gene into the camelina plants so they expressed a tailored bacterial enzyme in the developing seed.

This redirected the plant’s usual metabolic pathways so rather than producing sinapine from the chemical, hydroxycinammic acid, they instead produced the 4-VP molecules, either in a free form or attached to plant sugars.

4-VP molecules have a whole range of applications within industry, with most of them being commonly used flavour and aroma compounds for food and cosmetic products.

One of them, 4-vinly guaiacol has a clove like taste and aroma, whilst 4-vinylsyringol – also known as Canolol – can be used as a food preservative.

4-vinyl phenol is used to make PVP, or polyvinylphenol, a plastic which is an integral part of most modern LCD screens. Such TFT (thin film transistor) screens display sharper and brighter images, and process movement more smoothly, than standard LCD screens.

The team were impressed by the accumulation of these 4-VP derivatives, with the bacterial gene driving a 95% reduction in sinapine content in seeds of both glasshouse and field-grown camelina.

The quantity of 4-VP derivatives produced was more than twice that of sinapine in wild type seeds, said the research team’s leader, Professor Peter Eastmond.

“This is a great start, but the ultimate goal is to get the plants to manufacture all the 4-VP molecules in their industrially useful free form.

“We anticipate that step may be doable with more conventional breeding methods.”


Dr Guillaume Menard

Molecular Biologist/Analytical Biochemist


Rothamsted Research is the longest-running agricultural research institute in the world. We work from gene to field with a proud history of ground-breaking discoveries in areas as diverse as crop management, statistical interpretation and soil health. Our founders, in 1843, were the pioneers of modern agriculture, and we are known for our imaginative science and our collaborative approach to developing innovative farm practice.
Through independent research, we make significant contributions to improving agri-food systems in the UK and internationally, with economic impact estimated to exceed £3 bn in annual contribution to the UK economy. Our strength lies in our systems approach, which combines strategic research, interdisciplinary teams and multiple partnerships.
Rothamsted is home to three unique National Bioscience Research Infrastructures which are open to researchers from all over the world: The Long-Term Experiments, Rothamsted Insect Survey and the North Wyke Farm Platform.
We are strategically funded by the Biotechnology and Biological Sciences Research Council (BBSRC), with additional support from other national and international funding streams, and from industry. We are also supported by the Lawes Agricultural Trust (LAT).


The Biotechnology and Biological Sciences Research Council is part of UK Research and Innovation, a non-departmental public body funded by a grant-in-aid from the UK government.
BBSRC invests to push back the frontiers of biology and deliver a healthy, prosperous and sustainable future. Through our investments, we build and support a vibrant, dynamic and inclusive community which delivers ground-breaking discoveries and develops bio-based solutions that contribute to tackling global challenges, such as sustainable food production, climate change, and healthy ageing.
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BBSRC proudly forges interdisciplinary collaborations where excellent bioscience has a fundamental role. We pioneer approaches that enhance the equality, diversity, and inclusion of talent by investing in people, infrastructure, technologies, and partnerships on a global scale.


The Lawes Agricultural Trust, established in 1889 by Sir John Bennet Lawes, supports Rothamsted Research’s national and international agricultural science through the provision of land, facilities and funding. LAT, a charitable trust, owns the estates at Harpenden and Broom's Barn, including many of the buildings used by Rothamsted Research. LAT provides an annual research grant to the Director, accommodation for nearly 200 people, and support for fellowships for young scientists from developing countries. LAT also makes capital grants to help modernise facilities at Rothamsted, or invests in new buildings.