SCIENCE

Prof. FREDERICA THEODOULOU

Tailoring Plant Metabolism (ISP) Leader

Plant Sciences

BIOGRAPHY

Freddie's research focuses on targeted protein degradation in plants, in particular the N-end rule pathway. A combination of genetics, quantitative proteomics and conventional biochemistry is used to probe the functions and substrates of E3 ligases; the lab is also developing tools to measure protein lifetime in plants. We have a particular interest in protein turnover and oxygen sensing, with a long-term goal of improving flood tolerance in crops. Rothamsted Research is a centre of excellence for plant lipid metabolism, and the lab belongs to the Lipid Signalling and Metabolism "supergroup". We have expertise in peroxisomal transport proteins (especially ABC transporters) involved in lipid catabolism and have also identified novel regulators of lipid breakdown via genetic screens. Our discovery, that targeted protein degradation plays a role in the control of lipid metabolism, unites the two main research themes of the lab.

TEL:

+44 (0) 1582 938 264

    ADDRESS:

    Rothamsted Research, Harpenden, AL5 2JQ

      SOCIAL MEDIA

      PROFESSIONAL PLATFORMS

      PUBLICATIONS

      • 2015
        Theodoulou, F. L.

        Science on screen: what's the drama about accuracy?

        Biochemist 37(6) : pp.3

      • 2015
        Theodoulou, F. L.

        Who wants to live forever?

        Biochemist 37(4) : pp.3

      • 2015
        Theodoulou, F. L.

        Writer's block: seeking the muse when caffeine fails

        Biologist 37(3) : pp.3

      • 2015
        Theodoulou, F. L.

        Bang the gong for biochemistry

        Biochemist 37(1) : pp.3

      • 2015
        Theodoulou, F. L.

        Keeping an open mind: Sherlock Holmes and the RNA world

        Biochemist 37(2) : pp.3

      • 2014
        Theodoulou, F. L.

        Band of boffins

        Biochemist 36(6) : pp.3

      • 2014
        Theodoulou, F. L.

        Death, taxes...and metrics

        Biochemist 36(5) : pp.3

      • 2014
        Theodoulou, F. L.

        Scientific crises and the Bluetongue blueprint

        Biochemist 36(2) : pp.3

      • 2014
        Theodoulou, F. L.

        (Real) life after a PhD

        Biochemist 36(4) : pp.3

      • 2014
        Theodoulou, F. L.

        Replace, reduce, refine - and debate

        Biochemist 36(3) : pp.3

      • 2014
        Theodoulou, F. L.

        One click and it's gone: posterity in the electronic era

        Biochemist 36(1) : pp.3

      • 2013
        Theodoulou, F. L.

        The beauty of public engagement

        Biochemist 35(4) : pp.3

      • 2013
        Theodoulou, F. L.

        The biochemistry of bad behaviour

        Biochemist 35(6) : pp.3

      • 2013
        Theodoulou, F. L.

        What have plants done for us?

        Biochemist 35(5) : pp.3

      • 2013
        Theodoulou, F. L.

        Floral monsters and murderous mirror images

        Biochemist 35(2) : pp.3

      • 2013
        Theodoulou, F. L.

        Getting an even break

        Biochemist 35(3) : pp.3

      • 2013
        Theodoulou, F. L.

        The impact agenda: when Gladstone met Faraday

        Biochemist 35(1) : pp.3

      • 2012
        Theodoulou, F. L.

        Reinventing the polytechnic?

        Biologist 34(4) : pp.3

      • 2012
        Theodoulou, F. L.

        Science under siege

        Biochemist 34(5) : pp.3

      • 2012
        Theodoulou, F. L.

        Could Jurassic Park ever come true?

        Biochemist 34(6) : pp.3

      Pages

      Strategic programme

      • Tailoring Plant Metabolism (TPM)

      Science project

      • Cleavage of acyl-CoA by peroxisomal ABC subfamily D transporters in peroximes:mechansim and functional roles

      PhD project

      • Molecular characterisation of the plant N-end rule, a pathway of agricultural importance

      QUALIFICATIONS

      • 1992 - DPhil, Department of Plant Sciences, University of Oxford, UK
      • 1989 - BA (Hons), first class, Botany, University of Oxford, UK

      MEASURES OF ESTEEM

      • 2015 - present - Honorary Professor (Plant Biochemistry), Department of Animal and Plant Sciences, University of Sheffield
      • 2010 -present - Science Editor, The Biochemist, magazine of the Biochemical Society
      • Membership representative, Biochemical Society Awards Committee
      • Steering Committee and founding member, UK Plant Sciences Federation
      • External PhD Examiner for numerous UK and overseas universities