SCIENCE

Prof. FREDERICA THEODOULOU

Tailoring Plant Metabolism (ISP) Leader

Plant Sciences

BIOGRAPHY

Freddie's research focuses on targeted protein degradation in plants, in particular the N-end rule pathway. A combination of genetics, quantitative proteomics and conventional biochemistry is used to probe the functions and substrates of E3 ligases; the lab is also developing tools to measure protein lifetime in plants. We have a particular interest in protein turnover and oxygen sensing, with a long-term goal of improving flood tolerance in crops. Rothamsted Research is a centre of excellence for plant lipid metabolism, and the lab belongs to the Lipid Signalling and Metabolism "supergroup". We have expertise in peroxisomal transport proteins (especially ABC transporters) involved in lipid catabolism and have also identified novel regulators of lipid breakdown via genetic screens. Our discovery, that targeted protein degradation plays a role in the control of lipid metabolism, unites the two main research themes of the lab.

TEL:

+44 (0) 1582 938 264

    ADDRESS:

    Rothamsted Research, Harpenden, AL5 2JQ

      SOCIAL MEDIA

      PROFESSIONAL PLATFORMS

      PUBLICATIONS

      • 2004
        Theodoulou, F. L.,He, X.,Lao, S-H.

        Conjugation and transport of xenobiotics and natural products

        : S226

      • 2003
        Bartoli, C. G.,Millar, A. H.,Mittova, V.,Kiddle, G.,Heazlewood, J. L.,Theodoulou, F. L.,Foyer, C. H.

        Control of ascorbate synthesis by respiration and its implications for stress responses

        : 34-35

      • 2002
        Theodoulou, F. L.

        Getting to grips with ABCs

        : S143

      • 2002
        Theodoulou, F. L.,He, X-L.,Deery, M.,Razzaq, A.,Dupree, P.,Lilley, K.

        Identification of plant vacuole-specific proteins using the GARNet proteomics facility

        : S141

      • 2001
        Kiddle, G.,Theodoulou, F. L.,Foyer, C. H.,Barlow, P. W.

        Metabolic and in situ approaches to understanding the role of ascorbate in the cell cycle in maize roots

        In Abstracts SEB Annual Meeting, Canterbury, 2-6 April 2001 : C4.07

      • 2001
        Lao, S-H.,Cole, D.,Edwards, R.,Theodoulou, F. L.,Coleman, J. O. D.

        Role of 3,4-dichloroaniline N-malonyltransferase in the detoxification of xenobiotics

        In Abstracts COST Action 837 Meeting, Grenoble, 27-29 September 2001

      • 2001
        Swarbreck, D.,O'sullivan, D.,Edwards, D.,Ripoll, P-J.,Edwards, K.,Theodoulou, F. L.

        The MRP gene family in monocots - comparisons with Arabidopsis

        In Abstracts 12th International Workshop on Plant Membrane Biology, Madison, 11-16 August 2001

      • 2001
        Brown, D. A.,Cole, D. J.,Theodoulou, F. L.

        MRP and oxidative stress: do yeast and plants do things differently?

        In Abstracts 12th International Workshop on Plant Membrane Biology, Madison, 11-16 August 2001

      • 2001
        Brown, D. A.,Cole, D. J.,Theodoulou, F. L.

        A role for Multidrug Resistance associated Protein (MRP) in plant responses to oxidative stress?

        In Abstracts SEB Annual Meeting, Canterbury, 2-6 April 2001 : P2.6

      • 1999
        Brown, D. A.,Cole, D. J.,Theodoulou, F. L.

        Cloning and characterisation of xenobiotic inducible MRP homologues from wheat

        In Abstracts Society for Experimental Biology Plant Transport Group Meeting, Southampton, 8-10 September 1999

      • 1999
        Theodoulou, F. L.,Clark, I. M.,Mitchell, V. J.,Moss, S. R.,Pallett, K. E.

        Role of ABC transporters in herbicide metabolism

        In Abstracts Society for Experimental Biology Plant Transport Group Meeting, Southampton, 8-10 September 1999

      • 1998
        Theodoulou, F. L.,Clark, I. M.,Pallett, K. E.,Hallahan, D. L.

        A herbicide safener-induced MRP homologue from wheat

        In Abstracts 11th International Workshop on Plant Membrane Biology, Cambridge, 9-14 August 1998 : 77

      • 1998
        Theodoulou, F. L.,Davies, T. G. E.,Hallahan, D. L.,Forde, B. G.

        HvMDR 2 - a novel P-glycoprotein homologue from barley

        In Abstracts 11th International Workshop on Plant Membrane Biology, Cambridge, 9-14 August 1998 : 78

      • 1997
        Zhou, J-J.,Theodoulou, F. L.,Miller, A. J.

        Characterization of low and high affinity nitrate cotransporters expressed in Xenopus oocytes

        In Abstracts Phytosfere '97, Dublin, 23-25 April 1997

      • 1997
        Zhou, J-J.,Trueman, L. J.,Theodoulou, F. L.,Forde, B. G.,Miller, A. J.

        Functional expression of the crnA high affinity nitrate transporter of Aspergillus nidulans in Xenopus oocytes

        In Abstracts SEB Plant Transport Group Workshop, Glasgow, 8-10 September 1997 : N6

      • 1996
        Trueman, L. J.,Dunn, S. M.,Jennings, A. J.,Onyeocha, I.,Theodoulou, F. L.,Zhang, H.,Zhou, J-J.,Miller, A. J.,Forde, B. G.

        Characterisation of high-affinity nitrate transporter homologues from higher plants

        In Abstracts SEB Plant Transport Group Workshop, Saltash, 23-25 September 1996

      • 1996
        Zhou, J-J.,Theodoulou, F. L.,Muldin, I.,Ingemarsson, B.,Miller, A. J.

        Characterization of low and high affinity nitrogen cotransporters expressed in Xenopus oocytes

        In Abstracts SEB Plant Transport Group Workshop, Saltash, 23-25 September 1996

      • 1995
        Zhou, J-J.,Theodoulou, F. L.,Muldin, I.,Ingemarsson, B.,Miller, A. J.

        Characterization of low affinity nitrogen cotransporters expressed in Xenopus oocytes

        In Abstracts 10th International Workshop on Plant Membrane Biology, Regensberg, August 1995 : R38

      • 1995
        Zhou, J-J.,Theodoulou, F. L.,Muldin, I.,Ingemarsson, B.,Miller, A. J.

        Characterization of low affinity nitrogen transporters expressed in Xenopus oocytes

        In Abstracts 4th International Symposium on Inorganic Nitrogen Assimilation, Darmstadt, 23-28 July 1995 : 144

      • 1995
        Theodoulou, F. L.,Zhou, J-J.,Miller, A. J.,Sanders, D.

        Kinetic characterisation and mutational analysis of STP1, an Arabidopsis H=/hexose cotransporter expressed in Xenopus oocytes

        In Abstracts International Conference on the Transport of Photoassimiltes, Canterbury, 13-17 August 1995 : 35

      Pages

      Strategic programme

      • Tailoring Plant Metabolism (TPM)

      Science project

      • Cleavage of acyl-CoA by peroxisomal ABC subfamily D transporters in peroximes:mechansim and functional roles

      PhD project

      • Molecular characterisation of the plant N-end rule, a pathway of agricultural importance

      QUALIFICATIONS

      • 1992 - DPhil, Department of Plant Sciences, University of Oxford, UK
      • 1989 - BA (Hons), first class, Botany, University of Oxford, UK

      MEASURES OF ESTEEM

      • 2015 - present - Honorary Professor (Plant Biochemistry), Department of Animal and Plant Sciences, University of Sheffield
      • 2010 -present - Science Editor, The Biochemist, magazine of the Biochemical Society
      • Membership representative, Biochemical Society Awards Committee
      • Steering Committee and founding member, UK Plant Sciences Federation
      • External PhD Examiner for numerous UK and overseas universities