HOW FUNGI ‘TASTE’ WHEAT COULD HOLD KEY IN CROP DISEASE FIGHT
Exploring how the hazardous FHB-causing fungus senses its surroundings during infections could help scientists give it a good licking
New research carried out at Rothamsted has examined how fungal cell surface receptors, which are like the taste receptors on our tongues, help Fusarium graminearum monitor and adapt to its host plant during infection.
The fungus is responsible for the world’s number one floral disease in cereals, Fusarium Head Blight (FHB), which attacks the grain and makes infected wheat dangerous to consume.
Rothamsted Plant Pathologist, Professor Kim Hammond-Kosack, said that G-protein coupled receptors - which monitor the status of their wheat host and allow the fungi to mount an appropriate biological response - are promising targets for controlling this and other fungal diseases.
“The options to control Fusarium floral infections in cereal crops are very limited at the moment. This is causing growers and processors in the food and feed industries a tremendous headache, and why Rothamsted has been looking to apply our considerable expertise in crop diseases to this problem.
“These results open up the possibility of devising novel ways to control FHB disease through either targeted drug development or by eliminating the signals these receptors perceive during a fungal attack.”
In a series of experiments the scientific team demonstrated that F. graminearum’s receptors are important in wheat infections. The team made a collection of fungal mutants lacking individual receptors and showed that the absence of one type of receptor, specific to fungi, allowed the wheat host to mount a stronger defence.
The team also showed that the removal of this receptor meant that the virulence on wheat was reduced, because various fungal processes required for infection were disrupted.
The research is published in PLOS Pathogens.
A former Rothamsted Research scientist who led the study said we still know very little about fungal G-protein coupled receptors.
Dr Neil Brown, who is now a lecturer at the University of Bath’s Department of Biology & Biochemistry, said: “G-protein coupled receptors have been studied extensively in humans, where around 40% of our pharmaceuticals target these human receptors, as they’re exposed on the cell surface, making them accessible to drugs, and they control important biological functions.
“Our results show that fungal receptors are important for Fusarium infection of wheat. By learning more about the structure and function of these fungal-specific receptors, and the compounds they detect, we may be able to develop new approaches to control FHB and other plant pathogens.”
UK outbreaks of FHB occur every few years, with the 2012 one leading to wheat crop losses of around 10%, whilst In other parts of the world such as the USA, Brazil and China, the disease causes severe crop losses and mycotoxin contamination problems for farmers at nearly every harvest.
The research was funded by the Biotechnology and Biological Sciences Research Council through its Future Leaders Fellowship Programme awarded to Dr Neil Brown.
About Rothamsted Research
Rothamsted Research is the longest-running agricultural research institute in the world. We work from gene to field with a proud history of ground-breaking discoveries, from crop treatment to crop protection, from statistical interpretation to soils management. Our founders, in 1843, were the pioneers of modern agriculture, and we are known for our imaginative science and our collaborative influence on fresh thinking and farming practices.
Through independent science and innovation, we make significant contributions to improving agri-food systems in the UK and internationally. In terms of the institute’s economic contribution, the cumulative impact of our work in the UK was calculated to exceed £3000 million a year in 20151. Our strength lies in our systems approach, which combines science and strategic research, interdisciplinary teams and partnerships.
Rothamsted is also home to three unique resources. These National Capabilities are open to researchers from all over the world: The Long-Term Experiments, Rothamsted Insect Survey and the North Wyke Farm Platform.
We are strategically funded by the Biotechnology and Biological Sciences Research Council (BBSRC), with additional support from other national and international funding streams, and from industry. We are also supported by the Lawes Agricultural Trust (LAT).
For more information, visit https://www.rothamsted.ac.uk/; Twitter @Rothamsted
1Rothamsted Research and the Value of Excellence: A synthesis of the available evidence, by Séan Rickard (Oct 2015)
The Biotechnology and Biological Sciences Research Council is part of UK Research and Innovation, a non-departmental public body funded by a grant-in-aid from the UK government.
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The Lawes Agricultural Trust, established in 1889 by Sir John Bennet Lawes, supports Rothamsted Research’s national and international agricultural science through the provision of land, facilities and funding. LAT, a charitable trust, owns the estates at Harpenden and Broom's Barn, including many of the buildings used by Rothamsted Research. LAT provides an annual research grant to the Director, accommodation for nearly 200 people, and support for fellowships for young scientists from developing countries. LAT also makes capital grants to help modernise facilities at Rothamsted, or invests in new buildings.