Rothamsted Research

where knowledge grows

sayanova

Olga Sayanova

Role(s):
Senior Research Scientist
Biological Chemistry & Crop Protection
Harpenden
Phone:
+44 (0) 1582 763 133 ext: +44 1582 938734
Location:
Rothamsted Research, West Common, Harpenden, Hertfordshire, AL5 2JQ
Past Projects
Project Leader
  • Genetic Improvement of Algae for Value Added Products (GIAVAP)
  • Molecular characterization and genotype development of transgenic Camelina accumulating high levels of omega-3 long chain polyunsaturated fatty acids
  • *Eng.synthetic pathways
Member
  • Rational metabolic engineering of oilseed fatty acid composition
  • Evaluating novel plant oilseeds enriched in omega-3 long-chain polyunsaturated fatty acids to support sustainable development of aquaculture
Scientific Papers

Vaezi R, Napier JA, Sayanova O. (2013)  Identification and Functional Characterization of Genes Encoding Omega-3 Polyunsaturated Fatty Acid Biosynthetic Activities from Unicellular Microalgae.  11, 5116-5129

Hamilton M, Haslam R, Napier JA, Sayanova O (2014) Metabolic engineering of microalgae for enhanced production of omega-3 long chain polyunsaturated fatty acids. Metabolic Engineering 22:3–9

Ruiz-Lopez N, Haslam RP, Usher SL, Napier JA, Sayanova O (2013) Successful high-level accumulation of fish oil omega-3 long-chain polyunsaturated fatty acids in a transgenic oilseed crop. The Plant Journal Dec, on-line

Ruiz-Lopez N, Haslam RP, Usher SL, Napier JA, Sayanova O (2013) Reconstitution of EPA and DHA biosynthesis in Arabidopsis: Iterative metabolic engineering for the synthesis of n-3 LC-PUFAs in transgenic plants. Metabolic Engineering 17:30-41

Haslam RP, Ruiz-Lopez N, Eastmond P, Moloney M, Sayanova O, Napier JA (2012) The modification of plant oil composition by metabolic engineering - better nutrition by design. Plant Biotechnology Journal 11: 157-168

Ruiz-Lopez N, Haslam R P, Venegas-Caleron M, Li T, Bauer J, Napier J A, Sayanova O. (2012) Enhancing the accumulation of omega-3 long chain polyunsaturated fatty acids in transgenic Arabidopsis thaliana via iterative metabolic engineering and genetic crossing. Transgenic Research. 21:1233-1243

Ruiz-Lopez N, Sayanova O, Napier J A, Haslam R P. (2012) Metabolic engineering of the omega-3 long chain polyunsaturated fatty acid biosynthetic pathway into transgenic plants. Journal of Experimental Biology. 63:2397-2410

Sayanova O, Ruiz-Lopez N, Haslam R P, Napier J A. (2012) The role of Δ6-desaturase acyl-carrier specificity in the heterologous expression of the LC-PUFA biosynthetic pathway in transgenic plants. Plant Biotechnology Journal, 10: 195-206 

Sayanova O., Napier JA. (2011) Transgenic oilseed crops as an alternative to fish oils. Prostagl., Leukotr. And Essential fatty acids, 85, 253-260

Sayanova O, Haslam R P, Venegas-Caleron M, Ruiz-Lopez N, Worhty C, Rooks P, Allen M, Napier J.A. (2011) Identification and characterisation of genes encoding the omega-3 polyunsaturated biosynthetic pathway from the coccolithophore E.huxleyi.  Phytochemistry 72: 594-600

Venegas-Calerón, M. Sayanova, O and Napier J. (2010) An alternative to fish oils: Metabolic engineering of oil-seed crops to produce omega-3 long chain polyunsaturated fatty acids. Progress in Lipid research.49:108-119

Ruiz-López, N., Haslam, R., Venegas-Calerón, M. , Larson, T., Graham, I, , Napier, A,,* and Sayanova, O. (2009)

The synthesis and accumulation of stearidonic acid in transgenic plants: a novel source of 'heart-healthy' omega-3 fatty acids. Plant Biotechnology J.7:704-716

 Sayanova O, Haslam R P, Venegas-Caleron M, Napier J A. (2007) Cloning and characterization of unusual fatty acid desaturases from Anemone leveillei: identification of an acyl-CoA C20 ?5-desaturase responsible for the synthesis of sciadonic acid. Plant Physiology 144: 455 - 567.

 Venegas-Caleron, M; Beaudoin, F; Sayanova, O, J.A Napier. (2007). JOURNAL BIOLOGICAL CHEMISTRY    Co-transcribed genes for long chain polyunsaturated fatty acid biosynthesis in the protozoon Perkinsus marinus include a plant-like FAE1 3-ketoacyl coenzyme A synthase. JOURNAL BIOLOGICAL CHEMISTRY    282: 2996-2007.

 Sayanova O, Haslam R P, Guschina I, Lloyd D, Christie W W, Harwood J L, Napier J A. (2006) A bi-functional D12, D15 desaturase from Acanthamoeba castellanii directs the synthesis of highly unusual n-1 series fatty acids. Journal Biological Chemistry 281: 36533 – 36541.

 Sayanova O, Haslam R P, Qi B, Lazarus C M, Napier J A. (2006) Identification of an alternative pathway C20 D8-desaturase from a non-photosynthetic organism, Acanthamoeba castellanii: identification of an atypical front-end desaturase. FEBS LETT 580 (8):1946-1952

 

Sayanova O, Haslam R P, Venegas Caleron M, Napier J A. (2006) Isolation of “front-end” desaturases with distinct n-6 or n-3 substrate preferences from Primula species. Planta, 224, 1269-1277

 Napier J A, Haslam R P, Venegas-Caleron M, Michaelson L V, Beaudoin F, Sayanova O. (2006) Progress towards the production of very long chain polyunsaturated fatty acid in transgenic plants: plant metabolic engineering comes of age Physiol Plantarum, 126 (3), 398-406

 

J.A. Napier and O. Sayanova, The production of very-long-chain PUFA biosynthesis in transgenic plants: towards a sustainable source of fish oils, Proc Nutr Soc 64 (2005), pp. 387–389.

 

Napier, JA, Beaudoin, F, Sayanova, O. Reverse engineering of long-chain polyunsaturated fatty acid biosynthesis into transgenic plants EUR J LIPID SCI TECH 107 (4): 249-255 APR 2005

 Tonon, T., Sayanova, O., Michaelson, L., Qing, R., Harvey, D., Larson, T., Li, Yi.,Napier, J., Graham, I. Fatty acid desaturases from microalga Thalassiosira pseudonana. FEBS J., 2005, 272, 3401-4412 

Napier JA, Beaudoin F, Michaelson LV, Sayanova OV. The production of long chain polyunsaturated fatty acids in transgenic plants by reverse engineering. BIOCHIMIE 86 (11): 785-792 NOV 2004

 

Napier JA, Sayanova O, Qi BX, Lazarus CM. Progress toward the production of very long chain polyunsaturated fatty acids in transgenic          plants. LIPIDS 39 (11): 1067-1075 NOV 2004

 de Gyves EM, Sparks CA, Sayanova OV, Lazzeri P, Napier JA, Jones HD. Genetic manipulation of gamma-linolenic acid (GLA) synthesis in a commercial variety of evening primrose (Oenothera sp.) PLANT BIOTECHNOL J 2 (4): 351-357 JUL 2004

 Qi, BX, Fraser, T, Mugford, S, Dobson G, Sayanova O, Butler J, Napier JA, Stobart AK, Lazarus CM. Production of very long chain polyunsaturated omega-3 and omega-6 fatty acids in plants. NAT BIOTECHNOL 22 (6): 739-745 JUN 2004

Whitney, HM, Sayanova, O, Pickett JA, Napier JA. Isolation and expression pattern of two putative acyl-ACP desaturase cDNAs from Bassia scoparia. J EXP BOT 55 (397): 787-789 MAR 2004

Sayanova, OV, Napier, JA Eicosapentaenoic acid: biosynthetic routes and the potential for synthesis in transgenic plants. PHYTOCHEMISTRY 65 (2): 147-158 JAN 2004

Whitney, HM, Michaelson, LV, Sayanova, O, Pickett JA, Napier JA.. Functional characterisation of two cytochrome b5-fusion desaturases from Anemone leveillei: the unexpected identification of a fatty acid Δ6-desaturase. PLANTA 217 (6): 983-992 OCT 2003

Sayanova, OV, Beaudoin, F, Michaelson, LV,. Shewry PR, Napier JA. Identification of Primula  fatty acid Δ6-desaturases with n-3 substrate preferences. FEBS LETT 542 (1-3): 100-104 MAY 8 2003

 

Napier, JA, Michaelson, LV, Sayanova, O. The role of cytochrome b5 fusion desaturases in the synthesis of polyunsaturated fatty acids Prostaglandins Leukot Essent Fatty Acids. 2003 68 (2): 135-143 FEB

 Michaelson, LV, Longman, AJ, Sayanova, O, Stobart AK, Napier, J.A. Isolation and characterization of a cDNA encoding a Δ8 sphingolipid desaturase from Aquilegia vulgaris. BIOCHEM SOC Trans. 30: 1073-1075 Part 6 NOV 2002

 

Beaudoin, F, Gable, K, Sayanova, O, Dunn T, Napier, JA. A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase J BIOL CHEM. 277 (13): 11481-11488 MAR 29 2002

 

Sayanova, O, Beaudoin, F, Libisch, B, Castel A, Shewry PR, Napier JA. Mutagenesis and heterologous expression in yeast of a plant Δ6-fatty acid desaturase. J EXP BOT 52 (360): 1581-1585 JUL 2001

 

Beaudoin, F., Michaelson, L., Hey, S., Lewis, M., Shewry, P., Sayanova, O., Napier, J. Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway. PNAS, 2001, 97, 6421-6426

 

Beaudoin F, Michaelson LV, Lewis MJ, , Shewry PR, Sayanova, O, Napier JA. Production of C20 polyunsaturated fatty acids (PUFAs) by pathway engineering: identification of a PUFA elongase component from Caenorhabditis elegans. Biochem Soc Trans 28: 661-663 Part 6 DEC 2000

 

Longman AJ, Michaelson LV, Sayanova O, Napier, JA,  Stobart KA. An unusual desaturase in Aquilegia vulgaris. Biochem Soc Trans. 2000, 28 (6), 641-3

 

Sayanova O, Beaudoin F, Libisch B, Shewry PR, Napier JA. Mutagenesis of the borage Delta(6)-fatty acid desaturase. . Biochem Soc Trans. 2000, 28 (6), 636-8

 

Whitney H, Sayanova O, Lewis MJ, Pickett J. Napier JA. Isolation and expression pattern of two putative acyl-ACP desaturase cDNAs from Bassia scoparia. Biochem Soc Trans. 2000, 28 (6), 623-4

 Sayanova , O., Shewry, P., Napier, J. Histidine-41 of the cytochrome b5 domain of the borage  D6 fatty acid desaturase is essential for enzyme activity. Plant Physiology, 1999, 121, 641-646

 

Napier, J.A., Sayanova O., Sperling, P., Heinz, E. A growing family of cytochrome b5 -domain fusion proteins. Trends plant Science. 1999, 4, 2-4

 

Sayanova , O., Shewry, P., Napier, J. Characterisation and expression of a fatty acid desaturase from Borago officinalis. J. of Experim. Bot, 1999, 50, 411-412

 

Sayanova, O., Davies, G., Smith, M., Griffiths, G., Stobart, K., Shewry, P., Napier, J. Accumulation of D6  -unsaturated fatty acids in transgenic tobacco plants expressing a D6 desaturase from Borago officinalis. J. of Experim. Bot, 1999, 50, 1647-1652

 

Sayanova, O., Shewry, P., Napier, J. D6  -unsaturated fatty acids in species and tissues of the Primulaceae. Phytochemistry, 1999, 52, 419-422.

 

Napier, J., Sayanova, O., Stobart, K., Shewry, P. A new class of cytochrome b5  fusion proteins. Biochem. J. 1997, 328, 717-720 

Sayanova, O., Smith, M.S., Lapinskas, P., Stobart, K., Dobson, G., Christie, W., Shewry, P.R., Napier, J. Expression of a borage desaturase cDNA containing an N-terminal cytochrome b5 domain results  in the accumulation of high levels of D6 desaturated fatty acids in transgenic tobacco. PNAS, 1997, 94, 4211-4216.

 

Shewry, P.R., Sayanova, O., Tatham, A.S., Tamas, L., Turner, M., Richard,G., Hickman, D., Fido, R., Halford, N.G., Greenfield,J., Grimwade, B., Thomson, N., Miles, M., Freedman, R., Napier, J. Structure, Assembley and Targeting of Wheat Storage Proteins. J.Plant Physiol 1995. 145,. 620-625.

 Sayanova,O.V., Mekhedov, S.L., Burketbaev, E., Shipkova, N.I., Ananiev, E.V. Structural organization of C-hordein genes in barley. Genetica (Russian), 1994, 30, 749-755.

 

Sayanova, O.V., Mekhedov, S.L., Zhelnin, L.G., Khokhlova, T.A., Ananiev, E.V. Nucleotide sequence of barley C-hordein gene. Genetica (Russian). 1993,29, 1070-1079.

 

Sayanova, O.V., Pomortsev, A., Ladogina, M., Kadyrzhanova, D., Ananiev, E.V. Analysis of C-hordein deficient mutants of barley. Barley Genetics Newsletter, 1993, 22,53-56.

 

Mekhedov, S.L., Sayanova,O.V., Burketbaev, E., Khokhlova, T., Ananiev, E. Cloning and study of the structure of barley storage protein genes. Proceedings of the Sixth International Barley Genetics Symposium, Helsingborg, 1991,1, 154-156.

 Sayanova, O., Evgenyev, M., Chernyshev, A., Korochkin, L. Study of dispersed elements isolated from related species of the virilis group of Drosophila. Genetica (Russian), 1987, 25

 

Sayanova, O., Chumakov, I., Prasolov, V., Zabarovsky, E. Molecular cloning and structural organisation of DNA fragments homologous to c-mos oncogene. Reports of the Academy of Sciences (Russian), 1983,268,1480-1483

 

Djukandjiev, S., Sayanova, O., Vaintraub, I., Shutov, A. Protein degradation and proteolytic activity in the cotyledons of germinating Phaseolus vulgaris seeds. Reports of the Acadamy of Sciences, 1980, 2, 48-52

 Conference papers.

 

Haslam, R P, Ruiz-Lopez N, Venegas Caleron M, Sayanova O V, Napier J A. (2009) Heterologous production of stearidonic acid in transgenic oilseeds by expressing Primula n-3 –specific fatty acid D6 desaturase. Gordon Plant Lipid Conference, Galveston, Texas, USA. 1st - 7th Feb.

Haslam R, Venegas Caleron M, Sayanova O, Napier J A, Larson, T R, Graham I A, Zank, T Bauer J. (2008) Journey to LC-PUFA production in Plants: Moving from Models to Crops. Lipgene Meeting, Dublin, Ireland, 4-5th December.

Napier, J.A., O. Sayanova, Haslam R, T.Li, N. Ruiz Lopez. (2008) Rational Metabolic Engineering of Transgenic Plants for the Biosynthesis of Omega-3 Polyunsaturates. 6th Eurofed Lipid Congress Athens, Greece. 7- 10th September.

Napier, J.A., Ruiz Lopez, N., Li, T., Venegas Caleron, M., Haslam R., Sayanova, O. (2008) Optimising the accumulation of long chain polyunsaturates in transgenic plants. 18th International Symposium on Plant Lipids, Bordeaux, France, 20-25th July.

Ruiz-Lopez, N., Haslam, R., Sayanova, O.V., Napier, J.A. (2008) Heterologous production of stearidonic acid in transgenic oilseeds by expressing Primula n-3 –specific fatty acid D6 desaturase. 18th International Symposium on Plant Lipids, Bordeaux, France, 20-25th July.

Sayanova, O.V., Li T., Ruiz-Lopez, N., Haslam, R., Napier, J.A. (2008) Enhancing ω - 3 LC-PUFAs biosynthesis in transgenic plants. 18th International Symposium on Plant Lipids, Bordeaux, France, 20-25th July.

Napier, J.A., Sayanova, O. Haslam, R. Li, T. Ruiz Lopez, N. (2008). Rational Metabolic Engineering of Transgenic Plants for the Biosynthesis of Omega-3 Polyunsaturates. 6th Euro Fed Lipid Congress: Oils, Fats and Lipids in the 3rd Millennium: Challenges, Achievements and Perspectives, Athens, 7-10 September

Napier J A, Sayanova O, Haslam R P, Venegas Caleron M.  (2007) The production of very long chain fatty acids in transgenic plants. International Plant protection Congress. Glasgow 15 -18 October.

Haslam R P, Venegas Caleron M, Sayanova O, Napier J A. (2007) Prospecting for LC-PUFA in Plants.  Research Day. 5 October Rothamsted Research.

Sayanova O, Haslam R P, Venegas Caleron M, Napier J A. (2007) The production of long chain fatty acids in Arabidopsis. 5th Euro Fed Lipid Congress. Gothenburg 9 -12 September.

Haslam R P, Venegas Caleron M, Sayanova O, Napier J A. (2007) The production of LC-PUFA in Arabidopsis. Plant Sciences Day. 12 July Rothamsted Research.

Haslam R P, Venegas Caleron M, Sayanova O, Napier J A. (2007) Engineering the production of very long chain polyunsaturated fatty acids (VLC-PUFA) in Arabidopsis. 3rd European Symposium on plant Lipids - from underpinning research to applications. York 1 - 4 April.

Napier J A, Haslam R P, Venegas Caleron M, Sayanova O. (2007) Rational metabolic engineering of transgenic plants for the synthesis of long chain polyunsaturated fatty acids. 3rd European Symposium on plant Lipids - from underpinning research to applications. York 1 - 4 April.

Sayanova O, Haslam R P, Venegas-Caleron M, Napier J A. (2007) Production of D5-non-methylene-interupted polyunsaturated fatty acids in transgenic Arabidopsis plants.  3rd European Symposium on plant Lipids - from underpinning research to applications. York 1 - 4 April

Sayanova O, Haslam R P, Venegas Caleron M, Napier J A. (2006) Fish oils from plants: the transgenic approach. 4th Euro Fed Lipid Congress - Fats, Oils and Lipids for a Healthier Future Madrid, 01-04 October.

Sayanova O, Haslam R P, Napier J A. (2006) The unusual desaturases from Acanthamoeba castellanii: molecular cloning and functional characterization. International Symposium on Plant Lipids, East Lansing, Michigan, USA, 15 - 21 July.

Napier J A, Venegas Caleron M, Haslam R P, Sayanova O. (2006) Reverse-engineering of very long chain polyunsaturated fatty acid biosynthesis into transgenic plants: constraints, bottlenecks and solutions. 17th International Symposium on Plant Lipids, East Lansing, Michigan, USA, 15 - 21 July.

Napier J A, Haslam R P, Venegas-Caleron, M, Michaelson L V, Beaudoin F, Sayanova O. (2005) The production of very long chain polyunsaturated fatty acid in transgenic plants as an alternative, sustainable source of health-beneficial fish oils. BCPC Crop Science & Technology, Scottish Exhibition & Conference Centre, Glasgow, 31st Oct – 2nd Nov.

 

Napier, J A, Haslam R P, Venegas Caleron M, Sayanova O. (2005) The Production of Long Chain Polyunsaturated Fatty Acids in Transgenic Plants: Towards a Sustainable Source of Fish Oils. GM crops ten years on. The Association of Applied Biologists, Homerton College, Cambridge, 14 – 16th December 2005.

 

Sayanova, O. Venegas-Caleron, M., Haslam, R.,  Sayanova, O. Napier, J.  Characterisation of Primula Δ6 desaturases with distinct substrate specificities in transgenic yeast and plants. Abstracts of the 2nd Symposium  of Euro Fed Lipid, Copenhagen, 2005, 37

 

M. Venegas-Caleron, R. Haslam, O. Sayanova, Napier, J. The production and Accumulation of very Long Chain PUFAs in Arabidopsis thaliana. Abstracts of the 2nd Symposium  of Euro Fed Lipid, Copenhagen, 2005, 62

 

Sayanova O, Beaudoin F, Michaelson, LV, Shewry PR, Napier JA. N-3 specific Δ6 desaturases from Primula species. Abstracts of the 7th ISPMB, Barcelona

 

Sayanova, OV., Beaudoin, F., Shewry, P.R. and Napier, J.A. Mutagenesis of the borage  D6 fatty acid desaturase. Proceedings of the 14th International Symposium on Plant Lipids, Cardiff, UK, 2000, 636-638

 

Whitney, H., Sayanova, O., Lewis, M.J., Pickett and Napier, J.A. Isolation of two putative acyl-acyl carrier protein desaturase enzymes from Kochia scoparia. Proceedings of the 14th International Symposium on Plant Lipids, Cardiff, UK, 2000, 623-624

 

Longman, A.J., Michaelson, L.V., Sayanova, O.V., Napier, J.A. and Stobart A.K. An unusual desaturase in Aquilegia vulgaris. Proceedings of the 14th International Symposium on Plant Lipids, Cardiff, UK, 2000, 641-643

 

Beaudoin, F., Michaelson, L.V., Lewis, M.J., Shewry, P.R. Sayanova, O.V. and Napier, J.A. Production of C20 polyunsaturated fatty acids (PUFAs) by pathway engineering:Identification of a PUFA elongase component from Caenorhabditis elegans. Proceedings of the 14th International Symposium on Plant Lipids, Cardiff, UK, 2000, 661-663

 

Sayanova, O.V., Beaudoin, F., Shewry, P.R. and Napier, J.A. Production of  D6 desaturated fatty acids in yeast. Abstracts for the 23rd World Congress and Exhibition of the International Society for Fat Research (IAF), Brighton, UK, 1999

 

Sayanova, O.V., Davies, G., Stobart, A.K., Shewry, P.R. and Napier, J.A. Expression of the borage  D6 desaturase gene in the fad mutants of Arabidopsis. The Proceedings of the 13th International Symposium on Plant Lipids, Sevilla, 1998, 152-154

 

Napier, J.A., Libisch, B., Stobart, A.K., Shewry, P. and Sayanova, O. Expression of plant and animal  D6-desaturases in transgenic oilseeds. The Proceedings of the 13th International Symposium on Plant Lipids, Srvilla, 1998, 641-643

 

Shewry, P.R., Napier, J.A., Sayanova O., Smith, M., Cooke, D.T., Stoker, K.G., Hill, D.J., Stobart, A.K., Lapinskas, P. The use of Biotechnology to develop new crops and products. In: The Domestication Production and Utilisation of New Crops; Practical Approachs. J.Smartt. 1997.

 

Sayanova, O.V., Napier, J., Shewry, P.R.. Co-expression of wheat storage proteins and higher plant chaperons in E.coli. Abstracts for 4th ISPMB Meeting, Amsterdam, 1994, 1155

 

Mekhedov, S.L., Sayanova,O.V., Burketbaev, E., Khokhlova, T., Ananiev, E. Cloning and study of the structure of barley storage protein genes. Proceedings of the Sixth International Barley Genetics Symposium, Helsingborg, 1991, 1, 154-156.

 

Books

 

Michaelson, L.V., Beaudoin, F., Sayanova, O., Napier, J.A. The production of long-chained polyunsaturated fatty acids in transgenic plants . Plant Biotechnology. 2005 (in press)

Napier JA, Beaudoin F, Michaelson LV,Sayanova OV. The production of long chain polyunsaturated fatty acids in transgenic plants. Genet Eng (NY). 2004 26 143-157

                 Shewry, P.R., Napier, J.A., Sayanova O., Smith, M., Cooke, D.T., Stoker, K.G., Hill, D.J., Stobart, A.K., Lapinskas, P. The use of Biotechnology to develop new crops and products. In: The Domestication Production and Utilisation of New Crops; Practical Approachs. J.Smartt. 1997.

 

Patents.

1.       Napier JA, Sayanova O, Haslam RP; Ruiz Lopez N (2011) The production of polyunsaturated fatty acids (PUFAs) in transgenic Camelina sp. plants (application submitted)

2.       Napier JA, Sayanova O, Hamilton M (2012) Recombinant algae. 1217524.6

3.       Napier JA, Sayanova O ( 2012) Delta 6 desaturases from Primulaceae, expressing plants and PUFA-containing oils. US 08329993 Patent Assignee: IACR Rothamsted Official Gazette of the United States Patent and Trademark Office Patents.

4.       Napier JA, Sayanova O (2012) Process for the production of arachidonic acid and/or eicosapentaenoic acid. US 08273958.BASF Plant Science GmbH Official Gazette of the United States Patent and Trademark Office

5.       Napier JA, Sayanova O, Venegas Caleron M (2012) Elongase and uses thereof. US 08119861, BASF Plant Science GmbH Source: Official Gazette of the United States Patent and Trademark Office Patents

 

·A process for the production of Delta 5-unsaturated fatty acids in transgenic organisms comprises transforming an organism with nucleic acid encoding a Delta 5-desaturase.

Inventor(s): Zank, Thorsten; Napier, Johnathan A.; Sayanova, Olga

Patent Number: US 07723574

May 25, 2010

Patent Assignee: BASF Plant Science GmbH

 

·Method for the production of polyunsaturated fatty acids

Inventor(s): Napier, Jonathan A.; Sayanova, Olga; Lazarus, Colin M.; Qi, Baoxiu; Heinz, Ernst; Zank, Thorsten; Zahringer, Ulrich

Patent Number: US 07714185

Patent Assignee: University of Bristol

May 11, 2010

   

• DELTA 6 DESATURASES FROM PRIMULACEAE, EXPRESSING PLANTS

AND PUFA-CONTAINING OILS

Inventor: NAPIER JOHNATHAN A [GB] ; SAYANOVA OLGA [GB]

Applicant: ROTHAMSTED [GB]

EC: C12N9/02L99; C12N15/82C4B4; (+1) IPC: A01H5/00; A01H11/00; A01K67/027;

(+44)

Publication info: US2009222955 (A1) — 2009-09-03

 

• DESATURASE AND METHOD FOR THE PRODUCTION OF

POLYUNSATURATED FATTY ACIDS IN TRANSGENIC ORGANISMS

Inventor: BAUER JOERG [DE] ; NAPIER JOHNATHAN A [GB] (+1)

Applicant: BASF PLANT SCIENCE GMBH [DE] ; BAUER JOERG [DE] (+2)

EC: C12N15/82C4B4; C12N9/02L99; (+1) IPC: C12N15/82; A01H5/00; C12N9/02;

(+7)

Publication info: WO2009133145 (A1) — 2009-11-05

 

• Method for the production of y-linolenic acid and/or stearidonic acid in transgenic

Brassicaceae and Linaceae

Inventor: NAPIER JOHNATHAN A ; OLGA SAYANOVA (+1)

Applicant: BASF PLANT SCIENCE GMBH

EC: C12N15/82C4B4; C12N9/02L IPC: C07K; C12N

Publication info: ZA200804660 (A) — 2009-08-26

 

• Nucleic Acid

Inventor: NAPIER JOHNATHAN A [GB] ; SAYANOVA OLGA [GB] (+1)

Applicant: BASF PLANT SCIENCE GMBH [DE]

EC: C12N15/82C4B4; C12N9/02L99; (+2) IPC: C12N15/85; A01H5/00;

A01K67/027; (+11)

Publication info: US2009019559 (A1) — 2009-01-15

 

• Process for the production of delta 5-unsaturated fatty acids in transgenic

organisms

Inventor: NAPIER JOHNATHAN A [GB] ; SAYANOVA OLGA [GB] (+1)

Applicant: BASF PLANT SCIENCE GMBH [DE]

EC: C12N15/82C4B4; C12N9/02L IPC: C12N15/82; A01H5/00; C12N5/10; (+7)

Publication info: EP1790731 (A2) — 2007-05-30

 

• PROCESS FOR THE PRODUCTION OF ARACHIDONIC ACID AND/OR

EICOSAPENTAENOIC ACID

Inventor: NAPIER JOHNATHAN A [GB] ; SAYANOVA OLGA [GB]

Applicant: ROTHAMSTED RES [GB] ; NAPIER JOHNATHAN A [GB] (+1)

EC: C12N15/82C4B4; C12N9/02L99; (+1) IPC: C12N9/02; C12N9/10; C12N15/82;

(+3)

Publication info: WO2007042510 (A2) — 2007-04-19

 

• Novel method for the production of polyunsaturated fatty acids

Inventor: NAPIER JOHNATHAN A [GB] ; SAYANOVA OLGA [GB] (+5)

Applicant: UNIV BRISTOL [GB]

EC: C12N9/02L99; C12N9/10C1; (+2) IPC: C12P13/00; C12N9/02; C12N9/10; (+7)

Publication info: US2006246556 (A1) — 2006-11-02

 

• Delta 6-desaturases from Primulaceae, expressing plants and PUFA-containing

oils

Inventor: NAPIER JOHNATHAN A PROF DR [GB] ; SAYANOVA OLGA DR [GB]

Applicant: ROTHAMSTED EX STATION [GB]

EC: C12N9/02L99; C12N15/82C4B4; (+1) IPC: A01H5/00; C12N15/53;

A01K67/027; (+31)

Publication info: EP1726652 (A2) — 2006-11-29

 

 

Popular articles

 

Sayanova, O. Gamma-linolenic acid. Biological Sciences, 1998, 11, 19-22

 

Qualifications

1992:

PhD in Plant Molecular Genetics (N.I.Vavilov Institute of General Genetics, Moscow)

1978:

MSc in Plant Biochemistry (University of Kishinev)

Measures of esteem

2014

  • Invited plenary speaker at the Microbial Lipids meeting, Hamburg, May

2013

  • â?¢ Invited plenary speaker at the Gordon Research Conference on Plant Lipids, Texas, USA
  • Plenary speaker at the Global omega-3 Summit, Brussels
  • Invited speaker at the Rank Prize meeting

2012

  • Key speaker at RRes Open research Day

2010

  • Invited plenary speaker at the 19th ISPL, Caerns
  • â?¢ Invited plenary speaker at the 9th ISSFAL meeting, Maastricht, the Netherlands

2008

  • Key speaker at RRES Open Research Day
  • Invited seminar at Ben-Gurion University of Negev, Israel

2007

  • Plenary speaker at the 5th Euro Fed Lipid Congress, Gothenburge
  • Plenary speaker at SEB meeting, Glasgow