Rothamsted Research

where knowledge grows

phillipa

Andy Phillips

Phone:
+44 (0) 1582 763 133 ext: +44 1582 938801
Location:
Rothamsted Research, West Common, Harpenden, Hertfordshire, AL5 2JQ
Past Projects
Principal Investigator
  • Understanding how DELLA-mediated transcription controls GA-responsive growth and development in Arabidopsis
Project Leader
  • Enhancing wheat field performance and response to abiotic stress with novel growth-regulatory allelles
  • Manipulation of wheat grain development for improved yield and processing
  • Lawes Trust Studentship: Interaction between dwarfing genes and the environment in the control of wheat stature
  • Investigating the role of flavonoid biosynthesis in coat-imposed dormancy to facilitate the breeding of white-grained varieties of wheat
  • Provision of tilling resources and platforms in wheat
  • BBSRC Quota studentship: Investigating genetic and environmental factors that control root and shoot architecture in wheat
Member
  • Improving the yield stability of durum wheat under Mediterranean conditions OPTIWHEAT
  • Understanding the signalling pathways that impact on plant architecture
  • Cereal seed composition and end use quality
  • BBSRC Quota Studentship: The role of Gibberellin signalling in reproductive development
  • Harper Adams Studentship: Understanding and regulating pre-maturity alpha-amylase activity to maintain high Hagberg falling number in wheat
  • Investigating the role of gibberellin signalling in the response to drought
  • Lawes Trust Studentship: Chemical genetic dissection of GA signalling
  • Phenotyping root function in wheat
  • Developing a cereal fertility pipeline(CerFip) for wheat and barley

Plackett, A.R.G., Powers, S.J., Fernandes-Garcia, N., Urbanova, T., Takebayashi, Y., Seo, M., Jikumaru, Y., Benlloch, R., Nilsson, O., Ruiz-Rivero, O., Phillips, A.L., Wilson, Z.A., Thomas, S.G., and Hedden, P. (2012). Analysis of the developmental roles of the Arabidopsis gibberellin 20-oxidases demonstrates that AtGA20ox1, -2 and -3 are the dominant paralogues. Plant Cell in press.

Pearce, S., Saville, R., Vaughan, S.P., Chandler, P.M., Wilhelm, E.P., Sparks, C.A., Al-Kaff, N., Korolev, A., Boulton, M.I., Phillips, A.L., Hedden, P., Nicholson, P., and Thomas, S.G. (2011). Molecular Characterization of Rht-1 Dwarfing Genes in Hexaploid Wheat. Plant Physiol. 157, 1820-1831.

Botticella, E., Sestili, F., Hernandez-Lopez, A., Phillips, A., and Lafiandra, D. (2011). High resolution melting analysis for the detection of EMS induced mutations in wheat SbeIIa genes. BMC Plant Biol. 11.

Ward, D.A., MacMillan, J., Gong, F., Phillips, A.L., and Hedden, P. (2010). Gibberellin 3-oxidases in developing embryos of the southern wild cucumber, Marah macrocarpus. Phytochemistry 71, 2010-2018.

Sestili, F., Botticella, E., Bedo, Z., Phillips, A., and Lafiandra, D. (2010). Production of novel allelic variation for genes involved in starch biosynthesis through mutagenesis. Molecular Breeding 25, 145-154.

Rakszegi, M., Kisgyorgy, B.N., Tearall, K., Shewry, P.R., Lang, L., Phillips, A., and Bedo, Z. (2010). Diversity of agronomic and morphological traits in a mutant population of bread wheat studied in the Healthgrain program. Euphytica 174, 409-421.

Parry, M.A.J., Madgwick, P.J., Bayon, C., Tearall, K., Hernandez-Lopez, A., Baudo, M., Rakszegi, M., Hamada, W., Al-Yassin, A., Ouabbou, H., Labhilili, M., and Phillips, A.L. (2009). Mutation discovery for crop improvement. J. Exp. Bot. 60, 2817-2825.

Mutasa-Gottgens, E., Qi, A.M., Mathews, A., Thomas, S., Phillips, A., and Hedden, P. (2009). Modification of gibberellin signalling (metabolism & signal transduction) in sugar beet: analysis of potential targets for crop improvement. Transgenic Res. 18, 301-308.

Rieu, I., Ruiz-Rivero, O., Fernandez-Garcia, N., Griffiths, J., Powers, S.J., Gong, F., Linhartova, T., Eriksson, S., Nilsson, O., Thomas, S.G., Phillips, A.L., and Hedden, P. (2008). The gibberellin biosynthetic genes AtGA20ox1 and AtGA20ox2 act, partially redundantly, to promote growth and development throughout the Arabidopsis life cycle. Plant J. 53, 488-504.

Rieu, I., Eriksson, S., Powers, S.J., Gong, F., Griffiths, J., Woolley, L., Benlloch, R., Nilsson, O., Thomas, S.G., Hedden, P., and Phillips, A.L. (2008). Genetic analysis reveals that C19-GA 2-oxidation is a major gibberellin inactivation pathway in Arabidopsis. Plant Cell 20, 2420-2436.

Parry, M.A.J., Madgwick, P.J., Bayon, C., Habash, D., Baudo, M., Tuberosa, R., Bort, J., Salah, H.B.H., Slafer, G., Al-Yassin, A., Ouabbou, H., Labihili, M., Natchit, M., and Phillips, A.L. (2008). TILLING for improved crop performance under stress conditions. Aspects Applied Biol., 111.

Dijkstra, C., Adams, E., Bhattacharya, A., Page, A.F., Anthony, P., Kourmpetli, S., Power, J.B., Lowe, K.C., Thomas, S.G., Hedden, P., Phillips, A.L., and Davey, M.R. (2008). Over-expression of a gibberellin 2-oxidase gene from Phaseolus coccineus L. enhances gibberellin inactivation and induces dwarfism in Solanum species. Plant Cell Rep. 27, 463-470.

De Grauwe, L., Chaerle, L., Dugardeyn, J., Decat, J., Rieu, I., Vriezen, W.H., Baghour, M., Moritz, T., Beemster, G.T.S., Phillips, A.L., Harberd, N.P., Hedden, P., and Van Der Straeten, D. (2008). Reduced gibberellin response affects ethylene biosynthesis and responsiveness in the Arabidopsis gai eto2-1 double mutant. New Phytol. 177, 128-141.

De Grauwe, L., Vriezen, W.H., Bertrand, S., Phillips, A., Vidal, A.M., Hedden, P., and Van der Straeten, D. (2007). Reciprocal influence of ethylene and gibberellins on response-gene expression in Arabidopsis thaliana. Planta 226, 485-498.

Bhattacharya, A., Davey, M., Power, B., Ward, D., Phillips, A., and Hedden, P. (2007). Genetic modification of plant stature by manipulation of gibberellin metabolism: An alternative to chemical growth regulators. Comparative Biochemistry and Physiology a-Molecular & Integrative Physiology 146, S275-S275.

Appleford, N.E.J., Wilkinson, M.D., Ma, Q., Evans, D.J., Stone, M.C., Pearce, S.P., Powers, S.J., Thomas, S.G., Jones, H.D., Phillips, A.L., Hedden, P., and Lenton, J.R. (2007). Decreased shoot stature and grain α-amylase activity following ectopic expression of a gibberellin 2-oxidase gene in transgenic wheat. J. Exp. Bot. 58, 3213-3226.

Prosser, I.M., Adams, R.J., Beale, M.H., Hawkins, N.D., Phillips, A.L., Pickett, J.A., and Field, L.M. (2006). Cloning and functional characterisation of a cis-muuroladiene synthase from black peppermint (Mentha x piperita) and direct evidence for a chemotype unable to synthesise farnesene. Phytochemistry 67, 1564-1571.

Griffiths, J., Murase, K., Rieu, I., Zentella, R., Zhang, Z.L., Powers, S.J., Gong, F., Phillips, A.L., Hedden, P., Sun, T.P., and Thomas, S.G. (2006). Genetic characterization and functional analysis of the GID1 gibberellin receptors in Arabidopsis. Plant Cell 18, 3399-3414.

Frigerio, M., Alabadi, D., Perez-Gomez, J., Garcia-Carcel, L., Phillips, A.L., Hedden, P., and Blazquez, M.A. (2006). Transcriptional regulation of gibberellin metabolism genes by auxin signaling in arabidopsis. Plant Physiol. 142, 553-563.

Beale, M.H., Birkett, M.A., Bruce, T.J.A., Chamberlain, K., Field, L.M., Huttly, A.K., Martin, J.L., Parker, R., Phillips, A.L., Pickett, J.A., Prosser, I.M., Shewry, P.R., Smart, L.E., Wadhams, L.J., Woodcock, C.M., and Zhang, Y.H. (2006). Aphid alarm pheromone produced by transgenic plants affects aphid and parasitoid behavior. Proc. Natl. Acad. Sci. USA 103, 10509-10513.

Appleford, N.E.J., Evans, D.J., Lenton, J.R., Gaskin, P., Croker, S.J., Devos, K.M., Phillips, A.L., and Hedden, P. (2006). Function and transcript analysis of gibberellin-biosynthetic enzymes in wheat. Planta 223, 568-582.

Lester, D., Phillips, A., Hedden, P., and Andersson, I. (2005). Purification and kinetic studies of recombinant gibberellin dioxygenases. BMC Plant Biol. 5, 19.

Jasinski, S., Piazza, P., Craft, J., Hay, A., Woolley, L., Rieu, L., Phillips, A., Hedden, P., and Tsiantis, M. (2005). KNOX action in Arabidopsis is mediated by coordinate regulation of cytokinin and gibberellin activities. Current Biology 15, 1560-1565.

Hedden, P., Phillips, A., Evans, D., and Wilkinson, M.D. (2005). Increasing seed yield of plants by manipulating GA biosynthesis (UK).

Desgagne-Penix, I., Eakanunkul, S., Coles, J.P., Phillips, A.L., Hedden, P., and Sponsel, V.M. (2005). The auxin transport inhibitor response 3 (tir3) allele of BIG and auxin transport inhibitors affect the gibberellin status of Arabidopsis. Plant J. 41, 231-242.

Bulley, S.M., Wilson, F.M., Hedden, P., Phillips, A.L., Croker, S.J., and James, D.J. (2005). Modification of gibberellin biosynthesis in the grafted apple scion allows control of tree height independent of the rootstock. Plant Biotechnol. J. 3, 215-223.

Prosser, I., Altug, I.G., Phillips, A.L., Konig, W.A., Bouwmeester, H.J., and Beale, M.H. (2004). Enantiospecific (+)- and (-)-germacrene D synthases, cloned from goldenrod, reveal a functionally active variant of the universal isoprenoid-biosynthesis aspartate-rich motif. Archives of Biochemistry and Biophysics 432, 136-144.

Phillips, A.L. (2004). Genetic and Transgenic Approaches To Improving Crop Performance via Hormones. In Plant Hormones: Biosynthesis, Signal Transduction, Action!, P.J. Davies, ed (Dordrecht: Kluwer), pp. 582-609.

Thomas, S.G., Hedden, P., and Phillips, A.L. (2003). Gibberellin 2-oxidase. In USPTO (US).

Ward, J.L., Gaskin, P., Brown, R.G.S., Jackson, G.S., Hedden, P., Phillips, A.L., Willis, C.L., and Beale, M.H. (2002). Probing the mechanism of loss of carbon-20 in gibberellin biosynthesis. Synthesis of gibberellin 3 alpha,20-hemiacetal and 19,20-lactol analogues and their metabolism by a recombinant GA 20-oxidase. J. Chem. Soc.-Perkin Trans. 1, 232-241.

Prosser, I., Phillips, A.L., Gittings, S., Lewis, M.J., Hooper, A.M., Pickett, J.A., and Beale, M.H. (2002). (+)-(10R)-germacrene A synthase from goldenrod, Solidago canadensis; cDNA isolation, bacterial expression and functional analysis. Phytochemistry 60, 691-702.

Hedden, P., Phillips, A.L., Rojas, M.C., Carrera, E., and Tudzynski, B. (2002). Gibberellin biosynthesis in plants and fungi: A case of convergent evolution? J. Plant Growth Regul. 20, 319-331.

Hay, A., Kaur, H., Phillips, A., Hedden, P., Hake, S., and Tsiantis, M. (2002). The gibberellin pathway mediates KNOTTED1-type homeobox function in plants with different body plans. Current Biology 12, 1557-1565.

Hedden, P., and Phillips, A.L. (2000). Gibberellin metabolism: new insights revealed by the genes. Trends Plant Sci 5, 523-530.

Hedden, P., and Phillips, A.L. (2000). Manipulation of hormone biosynthetic genes in transgenic plants. Curr. Opin. Biotechnol. 11, 130-137.

Hedden, P., and Phillips, A. (2000). Hormone engineering in plants. Biofutur, 46-48.

Curtis, I.S., Ward, D.A., Thomas, S.G., Phillips, A.L., Davey, M.R., Power, J.B., Lowe, K.C., Croker, S.J., Lewis, M.J., Magness, S.L., and Hedden, P. (2000). Induction of dwarfism in transgenic Solanum dulcamara by over- expression of a gibberellin 20-oxidase cDNA from pumpkin. Plant J. 23, 329-338.

Curtis, I.S., Power, J.B., Hedden, P., Phillips, A., Lowe, K.C., Ward, D.A., and Davey, M.R. (2000). Transformation and characterization of transgenic plants of Solanum dulcamara L. - Incidence of transgene silencing. Ann Bot 86, 63-71.

Thomas, S.G., Phillips, A.L., and Hedden, P. (1999). Molecular cloning and functional expression of gibberellin 2-oxidases, multifunctional enzymes involved in gibberellin deactivation. Proc. Natl. Acad. Sci. USA 96, 4698-4703.

Lange, T., Graebe, J.E., Hedden, P., and Phillips, A.L. (1999). GA 20-oxidase gene sequences. United States Patent, 5,939,539.

Hedden, P., Phillips, A.L., Coles, J., Thomas, S., Appleford, N., Ward, D., Beale, M., and Lenton, J. (1999). Gibberellin biosynthesis: Genes, regulation and genetic manipulation. RIKEN Review 21, 29-30.

Curtis, I.S., Power, J.B., Hedden, P., Ward, D.A., Phillips, A., Lowe, K.C., and Davey, M.R. (1999). A stable transformation system for the ornamental plant, Datura meteloides DC. Plant Cell Rep. 18, 554-560.

Coles, J.P., Phillips, A.L., Croker, S.J., Garcia-Lepe, R., Lewis, M.J., and Hedden, P. (1999). Modification of gibberellin production and plant development in Arabidopsis by sense and antisense expression of gibberellin 20-oxidase genes. Plant J. 17, 547-556.

Williams, J., Phillips, A.L., Gaskin, P., and Hedden, P. (1998). Function and substrate specificity of the gibberellin 3-hydroxylase encoded by the Arabidopsis GA4 gene. Plant Physiol. 117, 559-563.

Phillips, A.L. (1998). Gibberellins in Arabidopsis. Plant Physiology and Biochemistry 36, 115-124.

Hedden, P., Coles, J.P., Phillips, A.L., Thomas, S.G., Ward, D.A., Curtis, I.S., Power, J.B., Lowe, K.C., Davey, M.R., Gray, D., Seymour, G.B., and Thomas, B. (1998). Modification of plant morphology by genetic manipulation of gibberellin biosynthesis. In Genetic and Environmental Manipulation of Horticultural Crops, K.E. Cockshull, ed (Wallingford, UK: CABI Publishing), pp. 205-217.

Ward, J.L., Jackson, G.J., Beale, M.H., Gaskin, P., Hedden, P., Mander, L.N., Phillips, A.L., Seto, H., Talon, M., Willis, C.L., Wilson, T.M., and Zeevaart, J.A.D. (1997). Stereochemistry of the oxidation of gibberellin 20-alcohols, GA(15) and GA(44), to 20-aldehydes by gibberellin 20-oxidases. Chemical Communications, 13-14.

Toyomasu, T., Kawaide, H., Sekimoto, H., vonNumers, C., Phillips, A.L., Hedden, P., and Kamiya, Y. (1997). Cloning and characterization of a cDNA encoding gibberellin 20-oxidase from rice (Oryza sativa) seedlings. Physiol. Plant. 99, 111-118.

Phillips, J., Artsaenko, O., Fiedler, U., Horstmann, C., Mock, H.P., Muntz, K., and Conrad, U. (1997). Seed-specific immunomodulation of abscisic acid activity induces a developmental switch. Embo Journal 16, 4489-4496.

MacMillan, J., Ward, D.A., Phillips, A.L., SanchezBeltran, M.J., Gaskin, P., Lange, T., and Hedden, P. (1997). Gibberellin biosynthesis from gibberellin A12-aldehyde in endosperm and embryos of Marah macrocarpus. Plant Physiol. 113, 1369-1377.

Lange, T., Kegler, C., Hedden, P., Phillips, A.L., and Graebe, J.E. (1997). Molecular characterisation of gibberellin 20-oxidases. Structure- function studies on recombinant enzymes and chimaeric proteins. Physiol. Plant. 100, 543-549.

GarciaMartinez, J.L., LopezDiaz, I., SanchezBeltran, M.J., Phillips, A.L., Ward, D.A., Gaskin, P., and Hedden, P. (1997). Isolation and transcript analysis of gibberellin 20-oxidase genes in pea and bean in relation to fruit development. Plant Mol. Biol. 33, 1073-1084.

Proebsting, W.M., Martin, D.N., Phillips, A.L., and Hedden, P. (1996). Regulation of GA 20-oxidase gene expression in Pisum sativum L. Plant Physiol. 111, 454-454.

Coles, J.P., Phillips, A.L., Valero, D., and Hedden, P. (1996). Genetic manipulation of gibberellin biosynthesis in Arabidopsis. Plant Physiol. 111, 97-97.

Phillips, A.L., Ward, D.A., Uknes, S., Appleford, N.E.J., Lange, T., Huttly, A.K., Gaskin, P., Graebe, J.E., and Hedden, P. (1995). Isolation and expression of three gibberellin 20-oxidase cDNA clones from Arabidopsis. Plant Physiol. 108, 1049-1057.

Huttly, A.K., and Phillips, A.L. (1995). Gibberellin-regulated plant genes. Physiol. Plant. 95, 310-317.

Huttly, A.K., and Phillips, A.L. (1995). Gibberellin-regulated expression in oat aleurone cells of two kinases that show homology to MAP kinase and a ribosomal-protein kinase. Plant Mol. Biol. 27, 1043-1052.

Hedden, P., Phillips, A.L., Jackson, G.S., and Coles, J.P. (1995). Molecular cloning of gibberellin biosynthetic enzymes, a route to the genetic manipulation of plant growth. In Proceedings of the Ninth Forum for Applied Biotechnology (Gent: Med. Fac. Landbouww Univ. Gent), pp. 1559-1566.

Williams, J., Bulman, M., Huttly, A., Phillips, A., and Neill, S. (1994). Characterization of a cDNA From Arabidopsis thaliana encoding a potential thiol protease whose expression is induced independently by wilting and abscisic acid. Plant Mol. Biol. 25, 259-270.

Phillips, A.L., and Huttly, A.K. (1994). Cloning of two gibberellin-regulated cDNAs from Arabidopsis thaliana by subtractive hybridization - expression of the tonoplast water channel, gamma-TIP, is increased by GA3. Plant Mol. Biol. 24, 603-615.

Lange, T., Hedden, P., and Phillips, A.L. (1994). Regulation of Plant Growth. In International Patent.

Huttly, A.K., Phillips, A.L., and Tregear, J.W. (1992). Localization of cis elements in the promoter of a wheat alpha-Amy2 gene. Plant Mol. Biol. 19, 903-911.

Kettleborough, C.A., Phillips, A.L., Keys, A.J., and Parry, M.A. (1991). A point mutation in the N-terminus of ribulose-1,5-bisphosphate carboxylase affects ribulose-1,5-bisphosphate binding. Planta 184, 35-39.

Kettleborough, C.A., Parry, M.A.J., Keys, A.J., and Phillips, A.L. (1990). Chimeras of the rubisco large subunit from wheat and Anacystis do not assemble into active enzyme in Escherichia coli. J. Exp. Bot. 41, 1287-1292.

Huttly, A.K., Plant, A.L., Phillips, A.L., Auffret, A.D., and Gray, J.C. (1990). Nucleotide sequence and transcripts of the pea chloroplast gene encoding CF0 subunit-III of ATP synthase. Gene 90, 227-233.

Phillips, A.L., Kettleborough, C.A., Parry, M.A.J., Burton, S., and Keys, A.J. (1987). Studies on structure and function of RuBP carboxylase oxygenase by construction of mutant and chimeric genes. Protein Engineering 1, 257-257.

Kettleborough, C.A., Parry, M.A.J., Burton, S., Gutteridge, S., Keys, A.J., and Phillips, A.L. (1987). The role of the N-terminus of the large subunit of ribulose- bisphosphate carboxylase investigated by construction and expression of chimaeric genes. Eur. J. Biochem. 170, 335-342.

Gutteridge, S., Phillips, A.L., Kettleborough, C.A., Parry, M.A.J., and Keys, A.J. (1986). Expression of bacterial Rubisco genes in Escherichia coli. Philosophical Transactions of the Royal Society of London Series B- Biological Sciences 313, 433-445.

Gray, J.C., Bird, C.R., Courtice, G.R.M., Hird, S.M., Howe, C.J., Huttly, A.K., Phillips, A.L., Smith, A.G., Willey, D.L., Bowman, C.M., and Dyer, T.A. (1986). Chloroplast genes for photosynthetic membrane-components of higher plants. Biochemical Society Transactions 14, 25-27.

Cozens, A.L., Walker, J.E., Phillips, A.L., Huttly, A.K., and Gray, J.C. (1986). A sixth subunit of ATP synthase, an F0 component, is encoded in the pea chloroplast genome. Embo Journal 5, 217-222.

Phillips, A.L. (1985). Restriction map and clone bank of tomato plastid DNA. Current Genetics 10, 147-152.

Phillips, A.L. (1985). Localization of genes for chloroplast components in tomato plastid DNA. Current Genetics 10, 153-161.

Willey, D.L., Phillips, A.L., and Gray, J.C. (1984). Chloroplast genes for components of the cytochrome bf complex from pea. Biochemical Society Transactions 12, 271-272.

Phillips, A.L., and Gray, J.C. (1984). Location and nucleotide sequence of the gene for the 15.2 kDa polypeptide of the cytochrome-bf complex from pea chloroplasts. Mol. Gen. Genet. 194, 477-484.

Phillips, A.L., and Gray, J.C. (1984). Synthesis of components of the cytochrome bf complex by isolated pea chloroplasts. Eur. J. Biochem. 138, 591-595.

Willey, D.L., Huttly, A.K., Phillips, A.L., and Gray, J.C. (1983). Localization of the gene for cytochrome f in pea chloroplast DNA. Mol. Gen. Genet. 189, 85-89.

Phillips, A.L., and Gray, J.C. (1983). Isolation and characterization of a cytochrome bf complex from pea chloroplasts. Eur. J. Biochem. 137, 553-560.

Shewry, P.R., Wan, Y., Wheeler, T., Gooding, M., Poole, R., Edwards, K.J., Mills, E.N.C., Skeggs, P., Gezan, S., Welham, S., Shenton, C., Zhu, T., Phillips, A., Jones, H.D., Li, L., Ward, J., Freeman, J., Nemeth, C., and Mitchell, R.A.C. Improving wheat for nutrition and processing. In Cereal science and technology for feeding ten billion people: genomics era and beyond. Proceedings of the meeting of the Eucarpia Cereal Section, Lleida, Spain, 13-17 November 2006. (Centre International de Hautes Etudes Agronomiques Mediterraneennes), pp. 249-252.

 

 

Qualifications

1983:

PhD in Botany (Molecular biology) (University of Cambridge)

1979:

BA in Natural Sciences (Biol) (University of Cambridge)