Rothamsted Research

where knowledge grows

hammond

Kim Hammond-Kosack

Phone:
+44 (0) 1582 763 133 ext: +44 1582 938240
Location:
Rothamsted Research, West Common, Harpenden, Hertfordshire, AL5 2JQ
Past Projects
Principal Investigator
  • The genome sequence for the potato cyst nematode Globodera pallida and its utilisation for improved control
  • Genetics and mechanisms of resistance to diseases caused by viral and fungal pathogens in wheat, barley and related plant species
  • A functional genomics approach to the identification of genes determining fungal pathogenesis of cereals
  • Influence of host genotype on take-all inoculum build-up in the soil
  • BBSRC Industry CASE Studentship: Comparison of infection biology & transcriptome of wild-type & single gene deletion strains of Fusarium Graminearum
  • BBSRC Quota Studentship: A systems biology approach to explore host-pathogen interactions
  • BBSRC CASE Studentship: Factors allowing plant pathogens to detect and penetrate plant surfaces
  • BBSRC CASE Studentship Investigating fungal pathogen metabolism through targeted analysis of the Mycosphaerella graminicola Cytochrome P
  • *Dissection of wheat-Stagonospo
Project Leader
  • Exploitation of natural plant biodiversity for the presticide-free production of food (BIOEXPLOIT)
  • Pathogenicity of non-biotrophic fungi infecting cereals
  • The Wheat Genetic Improvement Network (WGIN) - Improving the environmental footprint of farming through crop genetics and targeted traits analysis
  • Protecting second wheat through the reduction of take-all inoculum build up: LOW TAB
  • BBSRC Quota Studentship: Functional evaluation of plant defence signalling against Fusarium graminearum and F.culmorum in Arabidopsis floral tissue
  • PhytoPath: an Integrated resource for comparative phytopathogen genomics
  • Protecting yield potential of wheat
  • Pathogen-Host Interactions Database: PHI Database
  • DTP Studentship: Exploring the genetic and mechanistic basis of resistance to Take-all disease in wheat
  • Functional genomic analysis of interactions between Mycoshaerella graminicola & wheat plants: investigating genes related to early stages of infection
  • Developing a cereal fertility pipeline(CerFip) for wheat and barley
  • Extension to Wheat Genetic lmprovement Network (WGIN)
  • Prebreeding extension WISP combined -S5354
  • BBSRC Embrapa - Using HIGS and si-RNA technologies to explore and control Fusarium Head Scab disease in wheat fields
Member
  • International workshop on virus-induced gene silencing in cereals
  • Enhancing Diversity in UK wheat through a public sector prebreeding programme
  • Soil resource interactions
  • Fungal effectors as activators of novel resistances in cereals
  • Enhancing Diversity in UK wheat through a public sector prebreeding programme: Wheat Institute Strategic Programme (WISP) extension
  • Combined with S5413 The Wheat Genetic Improvement Network (WGIN3) - Improving the resilience of UK wheat yield and quality through crop genetics and targeted traits analysis

Publications since 2007  Total : 54 original research articles, 8 invited review aricles (peer reviewed)  and 6 invited  encyclopedia and book chapters

Fungal pathogenicity  

Cuzick, A., Urban, M and Hammond-Kosack, K. E. (2008) Fusarium graminearum gene deletion mutants map1 and tri5 reveal similarities and differences in the pathogenicity requirements to cause disease on Arabidopsis and wheat floral tissue. New Phytologist 177, 990-1000.

 

- Motteram, J., Küfner, I., Deller, S., Brunner, F., Hammond-Kosack, K.E. , Nürnberger T., and Rudd, J. R. (2009) Molecular characterization and functional analysis of MgNLP; the sole NPP1-domain containing protein from the fungal wheat leaf pathogen Mycosphaerella graminicola Mol. Plant Microbe Interact. 22, 790-799.

 

- Rudd, J.J.,  Antoniw, A., Marshall, R.,  Motteram, J., Fraaije, B. and  Hammond-Kosack, K. E. (2010)  Identification and characterisation of Mycosphaerella graminicola secreted or surface-associated proteins with variable intragenic coding repeats. Fungal Genetics and Biology 47, 19–32.

 

-       Baldwin, T.K , Urban, M., Brown, N  and  Hammond-Kosack, K. E. (2010a)   A role for topoisomerase I in Fusarium graminearum and F. culmorum pathogenesis and sporulation.  Mol. Plant-Microbe Interact 23, 566-577.

 

-       Brown, N. A., Urban, M., van de Meene, A. M. L. and Hammond-Kosack, K. E. (2010) The infection biology of Fusarium graminearum: Defining the pathways of spikelet to spikelet colonisation in wheat ears. Fungal Biology 114, 555-571.

 

-       Baldwin, T. K., Gaffoor, I., Antoniw, J., Andries, C. , Guenther, J.,  Urban,M.,  Pitkin, J.,  Hammond-Kosack*, K. E.,  and Trail*F. (2010b) A partial chromosomal deletion caused by random plasmid integration resulted in a reduced virulence phenotype in Fusarium graminearum. Mol. Plant-Microbe Interact 23, 1083-1096. KHK and FT joint corresponding authors.

 

 -       Lowe, R.G.T, Allwood, J. W., Galster, A., Urban, M., Daudi, A., Canning, C.,  Ward, J.L.,  Beale, M. H. and   Hammond-Kosack, K.E. (2010) A combined 1H NMR and ESI-MS analysis to understand the basal metabolism of plant pathogenic Fusarium species. Mol. Plant-Microbe Interact 23, 1605-1618. 

 

-       Urban, M*., Motteram, J., Jing,H-C.,  Powers, S.,  Townsend, J., Devonshire, J., Pearman, I., Kanyuka, K.,  Franklin, J.  and Kim E. Hammond-Kosack, K. E.* (2011) Inactivation of plant infecting fungal and viral pathogens to achieve biological containment in drainage water using UV treatment. Journal of Applied Microbiology 110, 675-687  (*joint corresponding authors).  

 

-       Marshall, R., Kombrink, A., Motteram, J., Loza-Reyes, E. , Lucas,  J.A.  Hammond-Kosack, K. E. , Thomma, B.P.H.J. and Rudd, J. J.  (2011) Analysis of two in planta expressed LysM effector homologues from the fungus Mycosphaerella graminicola reveals novel functional properties and varying contributions to virulence on wheat. Plant Physiol. 156, 756-769.

 

-       Motteram, J. , Lovegrove,  A., Pirie,  E., Marsh, J., Devonshire, J., van der Meene, A., Hammond-Kosack, K. E. and Rudd, J.J. (2011). Aberrant protein N-glycosylation impacts upon infection-related growth transitions of the haploid plant pathogenic fungus Mycosphaerella graminicola  Molecular Microbiology 81, 415-433.

 

-       Brown, N., Bass, C., Baldwin, T.K., Chen, H., Massot, F., Carion, P.W.C., Urban, M., van de Meene, A. M. L., and Hammond-Kosack, K. E  (2011) Characterisation of the Fusarium graminearum – wheat floral interaction. Journal of Pathogens (2011) Article ID 626345, 9 pages.

 

-       Merhej, J., Urban, M., Dufresne,  Hammond-Kosack, K. E., . Richard-Forget, F.  and Barreau, C. (2011) The velvet gene, FgVe1, affects fungal development and positively regulates trichothecene biosynthesis and pathogenicity in Fusarium graminearum.  Mol. Plant Pathol. 13: 363-374. 

 

-       Lowe, R.,  Jubault, M.,  Canning, G., Urban, M.  and Hammond-Kosack, K.E. (2012)  The induction of mycotoxins by trichothecene producing Fusarium species.  Methods in Molecular Biology – Plant Pathogen Protocols,  Vol 825, Chapter 27 p439-455, DOI 10.1007/978-1-61779-501-5_27,  Springer Science-Business Media, (all authors contributed equally to this publication), (peer reviewed)  

 

-       Dean, R.,  van Kan, J. , Pretorius; Z., Hammond-Kosack, K. E.,  Di Pietro,  A.,  Spanu, P.,  Rudd, J. J.,  Dickman, M.,  Kahmann, R.,  Ellis , J.,  and Foster, G.D.   (2012) The Top 10 Fungal Pathogens in Molecular Plant Pathology.  Molecular Plant Pathology  13: 414–430 (invited review - all authors made equal contributions).

-       Geisser et al. (2013) (56 authors including Hammond-Kosack, K.E.) One fungus, one name: defining the genus fusarium in a scientifically robust way that preserves longstanding use. Phytopathology 103, 400-408.

-       Pasquali, M., Spanu, F., Scherm, B., Balmas, V., Hoffmann, L., Hammond-Kosack, K. E., Beyer, M. and  Migheli, Q (2013) FcSTUA from Fusarium culmorum controls wheat foot and root rot in a toxin dispensable manner. PLoS ONE 8, e0057429.

 

-       Cools, H.J. and Hammond-Kosack, K. E. (2013) Exploitation of genomics in fungicide research: current status and future perspectives. Molecular Plant Pathology (invited review) 14, 197-210.

 

-         Fan, J., Urban, M., Parker, J. E., Brewer, H. C., Kelly, S. L., Hammond-Kosack, K. E., Bart A. Fraaije, B. A., Liu, X. and Cools, H. J. (2013) Characterisation of the sterol 14α-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 paralogue function in wheat infection. New Phytologist 198, 821-835.

 

-         Urban and Hammond-Kosack, K. E (2013) Chapter 4 'Molecular genetics and genomic approaches to explore Fusarium infection on wheat floral tissue', p43-80  In: Fusarium genomics and molecular and cellular biology. Editors: Proctor, R. H. and Brown, D. Norwich: Horizon Scientific Press (UK), http://www.horizonpress.com/fusarium

 

-            Rudd, J.R., Kanyuka, K., Derbyshire, M., Hassani-Pak, K.,  Andongabo, A., Devonshire, J., Lysenko, A., Saqi, M., Desai, N. M., Powers, S. J., Hooper, J.,  Ambroso, L., Bharti, A., Farmer, A.,  Hammond-Kosack, K.E., Dietrich  R. A., and Courbot, M. (2015) Transcriptome and metabolite profiling the infection cycle of Zymoseptoria tritici on wheat (Triticum aestivum) reveals a biphasic interaction with plant immunity involving differential pathogen chromosomal contributions, and a variation on the hemibiotrophic lifestyle definition.  Plant Physiology 167, 1158-1185.  (accompanying RRes press release Jan 2015)

 

-            Lee, J.,  Kanyuka, K., Edwards, M., Millyard, L., Gatehouse, A.,   Rudd, J., Hammond-Kosack, K.,  Pain, N. and Sadanandom, A. (2015) Functional analysis of a wheat homeodomain protein, TaR1 suggests that chromatin remodeling may influence the dynamics of the switch to necrotrophic growth by the phytopathogenic fungus  Zymoseptoria tritici.  New Phytologist 206, 598-605. (accompanying RRes and BBSRC press release and BBC Radio 4 interview Feb  2015)

 

-         Urban, M.  King, R., Hassani-Pak, K.  and Hammond-Kosack, K.E. (2015) Whole-genome analysis of Fusarium graminearum insertional mutants identifies virulence associated genes and unmasks untagged chromosomal deletions. BMC Genomics  16, 261

  

-         Brown, N.A.  and Hammond-Kosack, K. E. (2015) Secreted bio-molecules in fungal plant pathogenesis, Chapter 19 in the book entitled  ‘Fungal Bio-molecules p263-310: Sources, Applications and Recent Developments (Eds: V. K. Gupta, S. Sreenivasaprasad, and Robert L. Mach)  Wiley – Blackwell ISBN: 978-1-118-95829-2,  pages 408,  Published April 2015

 

-            Rudd, J.R., Kanyuka, K., Derbyshire, M., Hassani-Pak, K.,  Andongabo, A., Devonshire, J., Lysenko, A., Saqi, M., Desai, N. M., Powers, S. J., Hooper, J.,  Ambroso, L., Bharti, A., Farmer, A.,  Hammond-Kosack, K.E., Dietrich  R. A., and Courbot, M. (2015) Transcriptome and metabolite profiling the infection cycle of Zymoseptoria tritici on wheat (Triticum aestivum) reveals a biphasic interaction with plant immunity involving differential pathogen chromosomal contributions, and a variation on the hemibiotrophic lifestyle definition.  Plant Physiology 167, 1158-1185  (with RRes press release)

 

-         Derbyshire, M.C., Michaelson, L., Parker, J., Kelly, S., Thacker, U., Powers, S.J., Bailey, A., Hammond-Kosack, K.E., Courbot, M. and Rudd, J. J.(2015). Functional analysis of cytochrome b5 reductase-mediated metabolism in the phytopathogenic fungus Zymoseptoria tritici reveals novel functionalities implicated in virulence. Fungal Genet. Biol. 82, 69-84.

 

-          Mauchline, T.H., Chedom-Fotso, D., Chandra, G., Samuels, T., Greenaway, N., Backhaus, A. , McMillan, V., Canning, G., Powers, S.J.., Hammond-Kosack, K.E., Hirsch, P.R., Clark, I.M., Mehrabi, Z., Roworth, J., Burnell, J., and Malone, J.G. (2015)  An analysis of Pseudomonas genomic diversity in take-all infected wheat fields reveals the lasting impact of wheat cultivars on the soil microbiota. Environmental Microbiology doi:10.1111/1462-2920.13038  (with a joint  press release by Rothamsted and the  John Innes Centre).

 

-          Brown, N.A., Urban, M. and Hammond-Kosack, K.E (2015) The trans-kingdom identification of negative regulators of pathogen hypervirulence. FEMS Microbiological Reviews (in press).

 

 

Bioinformatics analysis of fungal genomes and PHI-base

- Winnenburg, R., Baldwin, T.K., Urban, M.,  Rawlings, C., Kohler, J. and Hammond-Kosack, K.E. (2006) PHI-base: a new database for pathogen host interactions. Nucleic Acids Research 34, D459-D464.

 

- Baldwin, T.K , Winnenburg, R., Urban, M., Rawlings, C., Kohler, J. and Hammond-Kosack, K.E. (2006) PHI-base provides insights into generic and novel themes of pathogenicity.  Mol. Plant. Microbe Interact. 19, 1451-1462.

 

- Cuomo, C A,  et al. (2007)  The genome sequence of F. graminearum reveals localized diversity and pathogen specialization. Science 317, 1400-1402. This article includes three of my team members and myself as middle authors.  

 

- Winnenburg, R., Urban, M., Beacham,  A., Baldwin T.K., Holland, S., Lindeberg, M., Hansen, H., Rawlings, C., Hammond-Kosack, K.E. and  Köhler, J (2008) PHI-base update: Additions to the Pathogen Host Interaction Database. Nucleic Acids Research, Database issue, 36 D572-576 (KHK – corresponding author).

 

- Ma et al. (2010) Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium oxysporum. Nature 464, 367-373 (18th March 2010) 64 authors with one team member and myself as middle authors.

 

-       Goodwin, S.A.  … Antoniw, J. …. Cools, H. J. …. Hammond-Kosack, K. E.   Rudd, J. J.  …. Kema, G. H. J. (2011) The finished genome of the fungal wheat pathogen Mycosphaerella graminicola reveals dispensome structure, chromosome plasticity and stealth pathogenesis.  PLoS Genetics  7 (6), e1002070.   57 authors with three team members and myself as middle authors. 

 

-       Orchard, S., Al-Lazikani, B., Bryant, S.,  Clark, D., Calder, E., Dix, I., Engkvist, O., Forster, M., Gaulton, A., Gilson, M., Glen, R., Grigorov, M.,  Hammond-Kosack, K.E., Harland, L., Hopkins, A., Larminie, C., Lynch, N., Mann, R. K., Murray-Rust, P.,  Piparo, E. L., Southan, C., Steinbeck, C., Wishart, D., Hermjakob, H., Overington, J. and Thornton, J..  (2011) Minimum information about a bioactive entity (MIABE)  Nature Reviews: Drug Discovery 10, 661 – 669.

 

-       Antoniw, J . Beacham, A., Baldwin, T. K., Urban, M., Rudd, J. J. and Hammond-Kosack, K. E.   (2011) OmniMapFree: A unified tool to visualise and explore sequenced genomes.  BMC Bioinformatics  12:447.

 

-       Brown, N. A., Antoniw, J., and Hammond-Kosack, K. E  (2012) The predicted secretome of the plant pathogenic fungus Fusarium graminearum: A refined comparative analysis.  PLoS One 7:33731.

 

-       Amaral, A., Antoniw, J., Rudd, J.J., and Hammond-Kosack, K. E. (2012) Defining the predicted protein secretome of the fungal wheat leaf pathogen Mycosphaerella graminicola. PLoS ONE e0049904.

 

-       Bennett, L., Lysenko, A., Papageorgiou, L.G., Urban, M., Hammond-Kosack, K.E., Rawlings, C., Saqi, S. and Tsoka, S. (2012) Detection of multi-clustered genes and community structure for the plant pathogenic fungus Fusarium graminearum CMSB 2012, Lecture Notes in Computer Science 7605 pp69-86 (D. Gilbert and M Heiner (Eds.)

 

-       Lysenko, A., Martin Urban, M., Bennett, L., Tsoka, S., Janowska-Sejda, E., Rawlings, C., Hammond-Kosack, K.E* and Saqi, M (2013) Network-based data integration for selecting candidate virulence associated proteins in the cereal infecting fungus Fusarium graminearum. PLoS ONE e0067926 (*KHK corresponding author)

 

-       Lawler, K., Hammond-Kosack, K. E., Alvis Brazma, A. and Coulson, RMR (2013) Genomic clustering and co-regulation of transcriptional networks in the pathogenic fungus Fusarium graminearum BMC Syst Biol. 7, 52.

 

-       Urban, M., Pant, R., Raghunath, A., Irvine, A.G., Pedro, H., Hammond-Kosack, K.E. (2015) The Pathogen-Host Interactions database (PHI-base): Additions and future developments. Nucleic Acids Research, Database issue 43, D645–D655. (accompanying RRes and BBSRC press release Jan 2015)

 

-       Urban, M.  King, R., Hassani-Pak, K.  and Hammond-Kosack, K.E. (2015) Whole-genome analysis of Fusarium graminearum insertional mutants identifies virulence associated genes and unmasks untagged chromosomal deletions. BMC Genomics  16, 261

 

-        Heard, S., Brown, N. A.and Hammond-Kosack, K. E. (2015) An interspecies comparative analysis of the predicted secretomes of the necrotrophic plant pathogens Sclerotinia sclerotiorum and Botrytis cinerea. PloS One Volume: 10 (6)    e0130534.

 

-        King, R., Martin Urban, M., Hammond-Kosack, M.C.U.  Hassani-Pak, K. and Hammond-Kosack, K.E. (2015) The completed genome sequence of the pathogenic ascomycete fungus Fusarium graminearum. BMC Genomics 16, 544.

 

-       Urban, M., Irvine, A. G.  Cuzick, A. and Hammond-Kosack, K.E. (2015) Using the Pathogen-Host Interactions database (PHI-base) to investigate plant pathogen genomes and genes implicated in virulence. Frontiers in Plant Sciences 6, 605. doi: 10.3389/fpls.2015.00605

 

-          Pedro, H., Maheswari, U., Urban, M., Irvine, A. G., Cuzick, A., McDowall, M.D., Staines, M.D., Kulesha, E., Hammond-Kosack, K.E. and Paul Julian Kersey, P.J (2016) PhytoPath: an integrative resource for plant pathogen genomics. Nucleic Acids Research Database issue, due out Jan 2016  (in press)

 

 

  

Plant defence mechanisms and the genetic basis of host resistance

- Hammond-Kosack K.E. and Kanyuka K. (2007) Resistance genes (R genes) in plants – a review.  Encyclopaedia of Life Sciences, Wiley Interscience

 

- Rudd J.J., Keon J and Hammond-Kosack K. E. (2008) The wheat MAP-kinases TaMPK3 and TaMPK6 are differentially regulated at multiple levels during compatible disease interactions with Mycosphaerella graminicola. Plant Physiology 147, 802-815. 

 

- Cuzick, A., Lee, S., Gezan, S and Hammond-Kosack K. E. (2008)  NPR1 and EDS11 contribute to host resistance against Fusarium culmorum in Arabidopsis buds and flowers. Mol. Plant Pathol. 9, 697-704. 

 

- Lyons, R, Hammond-KosacK, K. E. and Kanyuka, K (2008) Identification and characterization of a novel efficient resistance response to the furoviruses SBWMV and SBCMV in barley. Mol. Plant Microbe Interact. 21, 1193-1204.

 

- Jing, H-C, Lovell, D., Gutteridge, R., Jenk, D. Kornyukhin, D. Mitrofanova, O. Kema, G., Hammond-Kosack, K E. (2008)   Phenotypic and genetic analysis of the Triticum monococcum -Mycosphaerella graminicola interaction. New Phytologist 179, 1121-1132. 

 

- Hammond-Kosack, K.E. and Rudd, J.R. (2008)  Plant resistance signalling hijacked by a necrotrophic fungal pathogen. Plant Signalling and Behaviour 3, 993-995.

 

- Cuzick, A., Maguire, K and Hammond-Kosack K. E. (2009) Lack of the plant signalling component SGT1b enhances disease resistance to Fusarium culmorum in Arabidopsis buds and flowers. New Phytologist 181, 901-912.

 

- Lyons, R., Yilmaz N.D.K., Powers, S., Hammond-Kosack, K.E.  and  Kanyuka, K (2009) Characterisation of two unusual features of resistance to Soil borne cereal mosaic virus in  hexaploid wheat: leakiness and gradual elimination of viral coat protein  from infected root tissues. Mol. Plant Microbe Interact. 22, 560-574

 

- Hofinger, B.J., Jing, H-C, Hammond-Kosack, K.E., Kanyuka, K. (2009) High-resolution melting analysis of cDNA-derived PCR amplicons for rapid and cost-effective identification of novel alleles in barley.  Theoretical and Applied Genetics 119 (5), 851-865.

 

- Jing, H-C, Bayon, C., Kanyuka, K., Berry, S., Wenzl, P.,  Hunter, E.,  Kilian, A.,  Hammond-Kosack, K.E.  (2009) DArT markers: diversity analyses, genomes comparison, mapping and integration with SSR markers in Triticum monococcum.  BMC Genomics 10:458. This article is ranked as ‘Highly Accessed’ by BioMed Central, with a total of 1281 downloads in the 1st  6 months.

 

-       Hofinger B. J.,  Russell J.R., Bass C. G.,  Baldwin, T. K., Reis, M. D., Henley, P.E., Li, Y., Macaulay, M., Waugh, R., Hammond-Kosack, K. E  and Kanyuka, K. (2011)  (2011) An exceptionally high nucleotide and haplotype diversity and a signature of positive selection for the eIF4E resistance gene in barley are revealed by allele mining and phylogenetic analyses of natural populations.   Molecular Ecology, 20 3653-3668. 

 

-       Deller, S., Hammond-Kosack, K.E.  and Rudd, J.J (2011)   The complex interactions between host immunity and non-biotrophic fungal pathogens of wheat leaves. Journal of Plant Physiology  168 (1) 63-71. 

 

-       McMillan, V. E., Hammond-Kosack, K.E.  and Gutteridge, R. J.  (2011) Evidence that wheat varieties differ in their ability to build-up inoculum of the take-all fungus, Gaeumannomyces graminis var. tritici, under a first wheat crop. Plant Pathology 60, 200-206.

 

-        Lee, W-S, Hammond-Kosack, K. E. and Kanyuka, K. (2012) Barley stripe mosaic virus-mediated tools for investigating gene function in cereal plants and their pathogens: VIGS, HIGS and VOX. Plant Physiology 160: 582-590 (review) (Front cover of the October issue)

 

-        Lee, W-S, Rudd, J. J., Hammond-Kosack, K. E. and Kanyuka, K. (2014) Mycosphaerella graminicola LysM effector-mediated stealth pathogenesis subverts recognition through both CERK1 and CEBiP homologues in wheat. Molecular Plant-Microbe Interactions 27, 236-243.

 

-        Hammond-Kosack, K.E. (2014). Biotechnology: Plant Protection. In: Neal Van Alfen, editor-in-chief. Encyclopedia of Agriculture and Food Systems, Vol. 2, San Diego: Elsevier; pp. 134-152. Part of a 5 volume series with 3752 pages

 

-        McMillan, V.E.,  Gutteridge, R.J. and Hammond-Kosack, K.E (2014) Identifying variation in resistance to the take-all fungus, Gaeumannomyces graminis var. tritici, between different ancestral and modern wheat species.  BMC Plant Biology 14, 212.

 

-        Brewer, H.C., Hawkins, N.D. and Hammond-Kosack, K.E. (2014) Mutations in the Arabidopsis homoserine kinase gene DMR1 confer enhanced resistance to Fusarium culmorum and F. graminearum BMC Plant Biology 14, 317

 

-        Lee W-S, Hammond-Kosack KE, and Kanyuka K (2014) In-planta transient expression systems for monocots. In: Recent Advances in Gene Expression and Enabling Technology in Crop Plants. Azhakanandam K, Silverstone A, Henry D, and Davey MR (Eds.). Springer Science and Business Media, USA.

 

-          Lee, W-S, Rudd, J. J., Hammond-Kosack, K. E. and Kanyuka, K. (2015) Deregulation of plant cell death through disruption of chloroplast functionality affects asexual sporulation of Zymoseptoria tritici on wheat. Molecular Plant-Microbe Interactions 28, 590-604.

 

-          Lee, J.,  Kanyuka, K., Edwards, M., Millyard, L., Gatehouse, A.,   Rudd, J., Hammond-Kosack, K.,  Pain, N. and Sadanandom, A. (2015) Functional analysis of a wheat homeodomain protein, TaR1 suggests that chromatin remodeling may influence the dynamics of the switch to necrotrophic growth by the phytopathogenic fungus  Zymoseptoria tritici.  New Phytologist 206, 598-605 (with press release by University of Durham, Rothamsted Research and the BBSRC).

 

-         Rudd, J.R., Kanyuka, K., Derbyshire, M., Hassani-Pak, K.,  Andongabo, A., Devonshire, J., Lysenko, A., Saqi, M., Desai, N. M., Powers, S. J., Hooper, J.,  Ambroso, L., Bharti, A., Farmer, A.,  Hammond-Kosack, K.E., Dietrich  R. A., and Courbot, M. (2015) Transcriptome and metabolite profiling the infection cycle of Zymoseptoria tritici on wheat (Triticum aestivum) reveals a biphasic interaction with plant immunity involving differential pathogen chromosomal contributions, and a variation on the hemibiotrophic lifestyle definition.  Plant Physiology 167, 1158-1185 (with press release by Rothamsted Research).

 

-        Brewer, H. C. and Hammond-Kosack, K.E. (2015) Host to a Stranger: Arabidopsis and Fusarium Ear Blight. Trends in Plant Sciences, 20, 651–663 (with Rothamsted Research press release involving a four page BioInfographic cartoon).

 

-           Hammond-Kosack, K.E. and Jones JDG (2015) Responses to Plant Pathogens, Chapter 21  in the book entitled  “ Biochemistry and Molecular Biology of Plants” p 984- 1050 Ed BB Buchanan, W Gruissem and RL Jones (2nd edition). Pp1423 American Society of Plant Physiology, Rockville, Maryland, USA

 

 

Significant other earlier publications which are still highly cited

 

Hammond-Kosack, K.E.  and Parker  J. E. (2003) Deciphering plant-pathogen  communication: Fresh perspectives for molecular resistance breeding. Current Opinions in Biotechnology 14, 177-193.    The most highly cited plant defence review in 2004 and 2005.

 

Urban, M., Daniels, S., Mott, E. and Hammond-Kosack, K.E. (2002) Arabidopsis is susceptible to the cereal head blight fungal pathogens Fusarium graminearum and Fusarium culmorum. The Plant Journal 32, 961-973

 

Hammond-Kosack, K.E. and Jones JDG (2000) Responses to Plant Pathogens In “ Biochemistry and Molecular Biology of Plants” p 1102- 1156 Ed BB Buchanan, W Gruissem and RL Jones. Pp1367 (1st Edition) American Society of Plant Physiology, Rockville, Maryland, USA.

 This award winning book has since been translated in 17 different languages.  

 

Torres, MA, Onouchi, H, Hamada, S, Hammond-Kosack, K.E. and Jones, J. (1998) Six Arabidopsis thaliana homologues of the human respiratory burst oxidase (gp91(phox)) Plant Journal 14, 365-370.

 

Hammond-Kosack, K.E.; Tang, SJ; Harrison, K, and Jones, J. (1998) The tomato Cf-9 disease resistance gene functions in tobacco and potato to confer responsiveness to the fungal avirulence gene product Avr9. The Plant Cell 10, 1251-1266.

 

Parniske, M; Hammond-Kosack, K.E.; Golstein, C, Thomas,  CM; Jones, DA, Harrison, K; Wulff, BBH and Jones, JDG (1997) Novel disease resistance specificities result from sequence exchange between tandemly repeated genes at the Cf-4/9 locus of tomato. Cell 91, 821-832.

 

Hammond-Kosack K.E. & Jones J.D.G.(1997) Plant disease resistance genes. Annual Review of Plant Physiology and Plant Molecular Biology 48, 573-605.

 

Hammond-Kosack K.E. & Jones J.D.G (1996). Inducible plant defence mechanisms and resistance gene function. The Plant Cell 8,1773-1791. This article has now been cited over 1000 times.

 

Jones, D. A., Thomas, C. M., Hammond-Kosack K.E., Balint-Kurti, P.J.and Jones J.D.G.(1994). Isolation of the tomato Cf-9  gene for resistance to Cladosporium fulvum by transposon tagging. Science 266, 789-793.

 

Hammond-Kosack K.E., Harrison K. and Jones J.D.G. (1994). Developmentally regulated cell death on expression of the fungal avirulence gene Avr9  in tomato seedlings carrying the disease resistance gene Cf-9Proceedings of the National Academy of Science  USA 91, 10445-10449.

 

Hammond-Kosack K.E., Jones D.A. & Jones J.D.G.(1994). Identification of genes required in tomato for full Cf-9  dependent resistance to Cladosporium fulvum. The Plant Cell  6, 361-374.

 

Hammond K. E., Lewis B.G. & Musa T.M. (1985). A systemic pathway in the infection of oilseed rape plants by Leptosphaeria maculansPlant Pathology 34, 557-567.  This single research result subsequently altered the entire global disease control strategy.

 

Qualifications

1985:

PhD in Plant Pathology (University of East Anglia, Norwich, UK)

1981:

BSc in Agricultural Botany (University of Wales, Aberystwyth)

Measures of esteem

2013

  • Monitoring Editor Plant Physiology

2012

  • Leader of the BBSRC National Capability - PHI-base: The Pathogen-Host Interaction Database was launched in 2005 and is available at www.PHI-base.org.uk