The Molecular Biology Notebook Online
A Beginners' Guide to Molecular Biology

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Homologous

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Similar in position and structure, but not necessarily in function, as applied to chromosome.

View Dr Chromo's lecture on 'Genetics'

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Pronounce:

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Related Links

This is a search for homologous in our database

• CATH: Protein Structure Classification: CATH is a novel hierarchical classification of protein domain structures, which clusters proteins at four major levels, class(C), architecture(A), topology(T) and homologous superfamily (H). Class, derived from secondary structure content, is assigned for more than 90% of protein structures automatically. Architecture, which describes the gross orientation of secondary structures, independent of connectivities, is currently assigned manually. The topology level clusters structures according to their toplogical connections and numbers of secondary structures. The homologous superfamilies cluster proteins with highly similar structures and functions. The assignments of structures to toplogy families and homologous superfamilies are made by sequence and structure comparisons.
• PALI Phylogeny and ALIgnment of homologous protein structures: This database provides structure based sequence alignments for homologous proteins of known 3-D structure. The alignments available include those of pairwise (two proteins at a time) and multiple (simultaneous superposition of all the structures in a family). The database also provides dendrograms depicting phylogenetic relationships based on sequence and structural similarities.
• Prodom: The ProDom protein domain database consists of an automatic compilation of homologous domains detected in the SWISS-PROT database (Bairoch A, Boeckmann B, 1991, Nucleic Acids Res., 19:2247-2249) by the DOMAINER algorithm (Sonnhammer, E.L.L. & Kahn, D., 1994, Protein Sci. 3:482-492). It has been devised to assist with the analysis of the domain arrangement of proteins. Here is a outline of what this ProDom server can do for you
• TmPrime: TmPrime is a computer program to design oligonucleotide sets for LCR- and PCR-based gene synthesis to construct man-made DNA sequences by assembling pools of oligonucleotides. The program divides the long input DNA sequence based on the user specified melting temperatures and assembly conditions, and dynamically optimizes the length of oligonucleotides to achieve homologous melting temperatures. The output reports the melting temperatures, oligonucleotide sequences, and potential formation of secondary structures in a PDF file which will be sent to you via email.

homologous on Wikipedia

homologous at Answers. com

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