The Molecular Biology Notebook Online
Read a bit before clicking on the image.
Haemophilia is a genetic disease. It is carried by a recessive allele on the X-chromosome. This hereditary disease rarely affects women. However, women can carry the gene. If a male has the recessive allele on his X-chromosome, he is a haemophiliac.
Try to work out the genotype of each person in this family. Start with Thomas : he is a haemophiliac. What is his genotype? You can now work out the genotype of the mother. She is not a haemophiliac, neither is her husband. Chloe married a non-haemophiliac person, and her children were not haemophiliac. Can you conclude anything about her genotype? What is the pourcentage chance she is haemophiliac? Nicole married John who is haemophiliac. One of her daughter is haemophiliac. What can you conclude about Nicole? You will get the answer to these questions by moving the clicking on the image.
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