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Useful LinksInsect Molecular Biology Group
New work has established that using piperonyl butoxide (PBO) as a pre-treatment on insects with enhanced metabolic enzymes can restore the efficacy of insecticides from a diverse range of chemical classes. Specific synergists have also been developed that can help characterise the metabolic mechanism conferring resistance.
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Khot, A.C., Bingham, G.V., Field, L.M. and Moores, G.D. (2008). A novel assay reveals blockade of esterases by piperonyl butoxide (PBO). Pest. Manag. Sci. (in press). Bingham, G., Gunning, R.V., Delogu, G., Borzatta, V., Field, L.M. and Moores, G.D. (2008). Temporal Synergism can enhance carbamate and neonicotinoid insecticidal activity against resistant crop pests.Pest Manag. Sci. 64, 81-85. Bingham, G, Gunning, R.V., Gorman, K., Field, L.M. and Moores, G.D. (2007). Temporal synergism by microencapsulation of piperonyl butoxide and α-cypermethrin overcomes insecticide resistance in crop pests. Pest. Man. Sci. 63, 276-281. Gunning, R. V., Moores, G. D., Jewess, P., Boyes, A. L., Devonshire, A. L. and Khambay, B.P.S. (2007). Use of pyrethroid analogues to identify key structural features for enhanced-esterase resistance in Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae). Pest. Manag. Sci. 63: 569-575. Gunning, R.V., Nicholson, I.C., Kemp, F.C., Borzatta, V., Cottade, E.L.A., Field, L.M. and Moores, G.D. (2006). Piperonyl butoxide restores the efficacy of Bacillus thuringiensis toxin in transgenic cotton against resistant Helicoverpa armigera. Biopesticides Intl. 2, 129-136. Young, S.J., Gunning, R.V. and Moores, G.D. (2005). The effect of piperonyl butoxide on pyrethroid-resistance-associated esterases in Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae). Pest Manag. Sci. 61, 397-401. Yang, Y., Wu, Y., Chen, S., Devine, G. J., Denholm, I., Jewess, P. J. and Moores, G. D. (2004). The involvement of microsomal oxidases in pyrethroid resistance in Helicoverpa armigera from Asia. Ins. Biochem. Mol. Biol. 34, 763-773. Field, L.M. and Blackman, R.L. (2003). Insecticide resistance in the aphid Myzus persicae (Sulzer): chromosome location and epigenetic effects on esterase gene expression in clonal lineages. Biol. J. Linnean Society 79, 107-113. Field, L.M. and Foster, S.P. (2002). Amplified esterase genes and their relationship with other insecticide resistance mechanisms in English field populations of the aphid, Myzus persicae (Sulzer). Pest. Manag. Sci. 58, 1-6. Hemingway, J., Field, L., and Vontas, J. (2002). An overview of insecticide resistance. Science 298, 96-97. |