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Dr. Maurice Moloney is the Director and Chief Executive of Rothamsted Research near London, UK. Rothamsted, a BBSRC Institute. Rothamsted is the oldest and largest agricultural research centre in Europe, with a mandate for Food Security, agricultural sustainability and adaptation of agriculture to the consequences of both climate change and depletion of fossil fuels. He is also the founder of SemBioSys and served as the company's President from 1994-1998 and then as Chief Scientific Officer from 1998-2010. He is also a Professor in the Department of Biological Sciences at the University of Calgary and held the Natural Sciences and Engineering Research Council of Canada (NSERC) Industrial Research Chair in plant biotechnology from 1995 until 2003.

Dr. Moloney's career in plant biotechnology spans more than 20 years. Prior to founding SemBioSys, he spent seven years as a Professor at the University of Calgary, pursuing research on seed-specific gene expression, herbicide resistance and the plant cell cycle. Previously, he was the head of the Cell Biology Group at Calgene Inc., where he developed the first transgenic oilseed plants using Canola as the model. This resulted in a landmark patent in plant biotechnology and eventually became the basis of RoundUp Ready® and Liberty Link® Canola, which now commands 85% of the Canola acreage in Canada, a market of more than $100 MM per annum.

Dr. Moloney has published more than 80 original research papers and is an inventor on 43 issued US patents and over 300 patents worldwide. He has served on the advisory board of the National Research Council's Plant Biotechnology Institute and has consulted for several biotechnology and agri-business companies. He has served on numerous Federal government committees including NSERC Council (the governing body of NSERC), CFI, National Research Council PBI (Canada) and the Networks of Centres of Excellence programs. He was the co-president of the International Society for Plant Molecular Biology (ISPMB) Congress in 2000 and serves on the ISPMB board. Dr. Moloney has received a number of prestigious awards, including two Alberta Science and Technology (ASTECH) Awards for leadership in Alberta Technology. He holds a Bachelor of Science degree in Chemistry from Imperial College, London, and was awarded his doctorate in plant biochemistry from De Montfort University/Leicester Polytechnic in the United Kingdom. He was honoured by the University of Lethbridge with a D.Sc. honoris causa in 2004.

Member

Project Leader

  Genomic and epigenetic regulation of Brassica oilseed traits

Brassica oilseed rape is the primary renewable vegetable oil grown in N. Europe and the main break crop in the cereal rotation, grown on increasing acreage in the UK. The variety of food and non-food end uses require continuity of supply, with consistent high yield and predictable seed composition. These need to be achieved with reduced levels of inputs and in variable growing environments.
The project integrates several approaches to develop an understanding of the genes and mechanisms underlying regulation of key traits affecting oilseed yield and composition.

Specific targets:
1. Using comparative genomics and quantitative genetics to resolve loci affecting seed development and associated traits
2. Establishing how the rate of seed development affects harvestable seed size and quality
3. Determining how epigenetic processes affect plant development in different environments

  New Investigator Start Up Funds

In order for newly appointed researchers to be able quickly to establish new projects within the context of the strategic remit of established ISPG it is frequently necessary to inject a modest amount of funding for laboratory consumables and small equipment. This is particularly the case if the laboratories which they are joining are financially fully committed to other projects. In response to the 2005 Visiting Group recommendations, Rothamsted Research has recently recruited two young molecular microbiologists to work in different but related areas of rhizosphere/soil biology. During 2008/09 a sum of £20,000 will be allocated from the IIA to enable these scientists to advance work quickly to the point where preliminary data will increase the prospects of them winning new competitive funding. It is anticipated that similar modest pump-priming funds will be required regularly and will be a permanent feature of the Institute Integration Award at a level that can be afforded given the available funds that already reside with established research groups.

  Pre-breeding research to support climate change adaptation and reduction of environmental footprint of oilseed rape: OREGIN

The activities and deliverables from OREGIN will address specific gaps in knowledge, information and resources that have been prioritised as essential to ensuring that LINK and other projects deliver directly via crop genetic improvement. As a result, it is expected that OREGIN will contribute to significant changes in farming over the coming decade.

The primary goal of OREGIN is to provide a comprehensive, stable and reliable platform of resources and information for the exploitation of genetic diversity, to underpin pre-breeding activities. By acting as the hub for the UK Oilseed Rape R&D sector, the project will enable the network of stakeholders to draw down strategic objectives to a set of crop-related themes and specific traits. The ongoing dialogue amongst the network will focus on identifying hypothesis-driven studies that enable beneficial crop traits to be dissected to a level that crop breeders can incorporate relevant alleles into breeding new varieties.

The key deliverables will take the form of a breeders and pre-breeding 'toolkit'. This requires:
i) genetic markers in the context of reference linkage maps;
ii) a defined range of germplasm representing significant, useful allelic variation;
iii) information to place these resources in context of trait variation amenable to breeding selection.

This will be achieved via the following objectives:
1. Maintain and develop OREGIN seed and pathogen genetic resources, and enable resolution and introgression of useful variation
2. Quantify and characterise genetic variation for key traits
3. Delivering the pre-breeding toolkit: provision of integrated information to maximise utilisation of genetic diversity.

Member

  Inverse Labex: Reciprocal research placement in Embrapa Brazil for UK scientist participating in the Embrapa-UK Labex programme

This activity is a reciprocal arrangement linked to the Embrapa-UK Labex programme based at Rothamsted. This entails a two year placement of an experienced Brazilian scientist at Rothamsted, funded mainly by Embrapa. The reciprocal programme is a 4-5 month placement of a Rothamsted scientist (John Lucas) in one of the Embrapa centres in Brazil, jointly funded by BBSRC and Rothamsted Research.

The specific activities are:
1. To conduct a research project on plant-pathogen interactions in Embrapa Genetic Resources and Biotechnology (CENARGEN) Brasilia
2. To network on behalf of UK agricultural and biological science to identify opportunities for collaboration and joint funding mechanisms.

  Molecular characterization and genotype development of transgenic Camelina accumulating high levels of omega-3 long chain polyunsaturated fatty acids

Research at Rothamsted has identified the genes required for the biosynthesis of high value omega-3 long chain polyunsaturated fatty acids and demonstrated the feasibility of using transgenic Arabidopsis plants to synthesis these fatty acids. More recently, we have transitioned from model to crop, establishing a transformation system for the Brassicaceae Camelina sativa (false flax). Camelina is well-established oilseed crop in N. America and has many agronomic advantages as a platform for the production of novel oils. We have generated transgenic Camelina lines which accumulate in excess of 20% EPA, which represents a significant breakthrough in attempts to make this ‘fish oil’ in plants. This project will generate the commercial proof of principle for the technology by establishing homozygous high EPA Camelina lines with detailed molecular and genotypic characterization and then use these plant lines to carry out an analysis of oil stability and also phenotypic performance. These studies will demonstrate the initial industrial feasibility for the novel oils and pave the way to secure a licensee through whom we can commercialise the technology.

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Nykiforuk, CL*, Shen, Y, Murray, E.W.,  Boothe, JG, Busseuil, D, Rheaume, E, Tardif, J-C, Reid, A and Moloney, M.M. (2010)  Expression and recovery of biologically active recombinant Apolipoprotein AIMilano from transgenic safflower (Carthamus tinctorius) seeds. Plant Biotechnology Journal  9  260-263

Boothe, JG,  Nykiforuk, CL,  Shen, Y,  Zaplachinski S, Szarka,  SJ.,  Kuhlman, PA,  Murray, EW, Morck, DW,  Moloney, M M  (2010)  Seed-based Expression Systems for Plant Molecular Farming.  Plant Biotechnology Journal   8 (5), 525–654

Olga P. Yurchenko, Cory L. Nykiforuk, Maurice M. Moloney, Ulf Ståhl , Antoni BanaÅ›, Sten Stymne and Randall J. Weselake  (2009) A 10 kDa acyl-CoA binding protein (ACBP) from Brassica napus enhances acyl exchange between acyl-CoA and phosphatidylcholine.  (2009) Plant Biotechnology Journal   7(7): 602-610

Weselake RJ, Shah S, Tang M, Quant PA, Snyder CL, Furukawa-Stoffer TL, Zhu W, Taylor DC, Zou J, Kumar A, Hall L, Laroche A, Rakow G, Raney P, Moloney MM, Harwood JL.  (2008)   Metabolic control analysis is helpful for informed genetic manipulation of oilseed rape (Brassica napus) to increase seed oil content.   J. Exp. Bot.  59,  3543-9..

Suriyamongkol P, Weselake R, Narine S, Moloney M, Shah S. (2007)  Biotechnological approaches for the production of polyhydroxyalkanoates in microorganisms and plants Biotechnol. Adv. 25 : 148-75.

Weselake RJ, Madhavji M, Szarka SJ, Patterson NA, Wiehler WB, Nykiforuk CL, Burton TL, Boora PS, Mosimann SC, Foroud NA, Thibault BJ, Moloney MM, Laroche A, Furukawa-Stoffer TL.  (2006) Acyl-CoA-binding and self-associating properties of a recombinant 13.3 kDa N-terminal fragment of diacylglycerol acyltransferase-1 from oilseed rape   BMC Biochem. 2006 Dec 27;7: 24.

Siloto, R., Findlay, K., Lopez-Villalobos, A., Yeung, E., Nykiforuk, C., Moloney, M.M., (2006) The Accumulation of Oleosins Determines the Size of Seed Oilbodies. The Plant Cell 18, 1961 - 1974

Nykiforuk, C., Boothe, J., Murray, L., Keon, R., Goren, J., Markley, N., Moloney, M.M. (2005) Transgenic Expression and Recovery of Biologically Active Recombinant Human Insulin from Arabidopsis Thaliana Seeds. The Plant Biotechnology Journal 3 pp 77-85

Al-Ahmad, H., Dwyer, J., Moloney, M.M., Gressel, J., (2006) Mitigation of establishment of Brassica napus transgenes in volunteers using a tandem construct containing a selectively unfit gene. Plant Biotechnology Journal 4, 7–21

Abell, B.M., Hahn, M., Holbrook, L.A., Moloney, M.M. (2004) Membrane Topology and Sequence Requirements for Oil Body Targeting of Oleosin.  The Plant Journal. 37:   461-70

Kühnel B, Alcantara, J., Boothe, J., van Rooijen, G., Moloney, M.M. (2003) Precise and Efficient Cleavage of Recombinant Fusion Proteins Using Mammalian Aspartic Proteases.  Protein Engineering.  Protein Engineering, Vol. 16 (10), 777-783.

Seon, J.H., Szarka, S.J.., Moloney, M.M. (2002) A Unique Strategy for Recovering Recombinant Proteins from Molecular Farming:   Affinity Capture on Engineered Oilbodies   Journal of Plant Biotechnology 4(3) pp. 95 – 101.

Abell, B. M., High, S., and Moloney, M.M. (2002) Membrane Protein Topology of Oleosin is Constrained by its Long Hydrophobic Domain.  Journal of Biological Chemistry, 277 (10) 8602-8610.

Nykiforuk, C.L., Furukawa-Stoffer, T.L., Huff, P.W., Sarna, M., Laroche A., Moloney M.M., Weselake, R.J. (2002)  Characterization of cDNAs Encoding Diacylglycerol Acyltransferase from Cultures of Brassica napus and Sucrose-Mediated Induction of Enzyme Biosynthesis.  Biochimica et Biophysica Acta 1580:   95-109.

Moloney, M.M. (2000) Molecular Farming Using Seeds as Hosts.  Seed Technology and its Biological Basis, Sheffield Academic Press, p. 226-256.

Weselake, R.J., Nykiforuk, C.L., Larochet, A., Patterson, N.A., Wiehler, W.B., Szarka, S.J., Moloney, M.M., Tari, L.W., Derekh, U. (2000) Expression and Properties of Diacylglycerol Acyltransferase from Cell-suspension Cultures of Oilseed Rape.  Biochemical Society Transactions 28(6): 684-686.

Weselake, R.J., Laroche, A., and Moloney, M.M., (2001) Molecular strategies for increasing oil content in canola. Final Report for Farming for the Future (AARI), project # 980810, 139 pages.

Moloney, M.M. (2000) Seeds as Repositories of Recombinant Proteins in Molecular Farming. Korean Journal of Plant Tissue Culture 27 (4): 283-297.

Crowe, A., Abenes, M., Plant, A., Moloney, M.M. (2000) The seed-specific transactivator, ABI3, induces oleosin gene expression.   Plant Science 151: 171-181.

Deckers, H., Moloney, M.M., and Baum, A. (1999) The case for recombinant production of pharmaceutical proteins in plants. Annual Reports in Medicinal Chemistry 34: 237-245

Hays, DB., Wilen, RW., Sheng, C., Moloney, M.M., and Pharis, RP. (1999) Embryo-specific gene expression in microspore-derived embryos of Brassica napus.  An interaction between abscisic acid and jasmonic acid.  Plant Physiology 119: 1065-1072

Saborio F, Moloney, M.M., Tung P and Thorpe TA (1999) Root induction in Pinus ayacahuite by co-culture with Agrobacterium tumefaciens strains.  Tree Physiology 19: 383-389

Ward KA, Holbrook LA, Lamb N, Abrams S, Reid DM and Moloney, M.M. (1999) Structural requirements for biologically active jasmonates:   Induction of protease inhibitors and seed specific proteins. Plant Growth Regulation  27: 49-56

Chaudhary S, Parmenter DL and Moloney, M.M. (1998) Transgenic Brassica carinata as a vehicle for the production of recombinant proteins in seeds.  Plant Cell Reports 17: 195-200

Kathiresan A, Nagarathna KC, Moloney, M.M., Reid DM and Chinnappa CC (1998) Differential regulation of 1-aminocyclopropane-1-carboxylate synthase gene family and its role in phenotypic plasticity in Stellaria longipes. Plant Molecular Biology  36: 265-274 

Kermouni A, Mahmoud SS, Wang S, Moloney, M.M. and Habibi HR (1998) Cloning a full-length insulin-like growth Factor-I complementary DNA in the goldfish liver and ovary and development of quantitative PCR method for its measurement.  Gen Comp Endocrin 111: 51-60

Layzell DB, Brisson N, Devine MD, Moloney, M.M., Taylor GJ, Timmer V, Yada RY and Wood K (1998) Plant biology and food science in Canada: a vision for the future. Can J Bot. 76: 355-364

Mahmoud SS, Wang S, Moloney, M.M. and Habibi HR (1998) Production of biologically active recombinant goldfish type II growth hormone in Escherichia coli.  Comparative Biochemistry and Physiology 120: 657-663

Abell BM, Holbrook LA, Abenes M, Murphy DJ, Hills MJ and Moloney, M.M. (1997) Role of the Proline Knot Motif in Oleosin Endoplasmic Reticulum Topology and Oil Body Targeting.   The Plant Cell 9: 1481-1493

Abenes M, Holbrook LA, Moloney, M.M. (1997) Transient expression and oil body targeting of an Arabidopsis oleosin-GUS reporter fusion protein in a range of oilseed embryos.  Plant Cell Reports 17: 1-7

Holbrook LA, Tung P, Ward KA, Reid DM, Abrams S, Lamb N, Wilson Quail J, Moloney, M.M. (1997) Importance of the chiral centres of jasmonic acid in the responses of plants: activities and antagonism between natural and synthetic analogues.  Plant Physiology 114: 419-428

Liu J-H, Selinger LB, Hu Y-J, Moloney, M.M., Cheng K-J and Beauchemin KA (1997) An endoglucanase from the anaerobic fungus Orpinomyces joyonii: characterization of the gene and its product. Canadian Journal of Microbiology 43: 477-485

Liu J-H, Selinger LB, Cheng K-J, Beauchemin KA and Moloney, M.M. (1997)  Plant seed oil-bodies as an immobilization matrix for a recombinant xylanase from the rumen fungus Neocallimastix patriciarum.  Molecular Breeding 3: 463-470.

Markley NA, Young D, Laquel P, Castroviejo M and Moloney, M.M. (1997) Molecular genetic and biochemical analysis of B. napus PCNA function.  Plant Molecular Biology 34: 693-700

Hays DB, Rose P, Abrams SR and Moloney, M.M. (1996) Biological activity of optically pure C-1 altered abscisic acid analogs in Brassica napus  microspore embryos.  J Plant Growth Regul 15: 5-11

Kühnel B, Holbrook LA, Moloney, M.M. and van Rooijen GJH (1996) Oil bodies of transgenic Brassica napus  as a source of immobilized ß-glucuronidase.  JAOCS 73: 1533-1538

Mahmoud SS, Moloney, M.M. and Habibi HR  (1996) Cloning and sequencing of the goldfish growth hormone cDNA.  Gen Comp Endocrin 101: 139-144

Zhang X-H, Moloney, M.M. and Chinnappa CC (1996) Analysis of an ABA- and osmotic stress inducible dehydrin from Stellaria longipes.  Journal of Plant Physiology 149: 617-622

Parmenter DL, Boothe JG, van Rooijen GJH, Yeung EC and Moloney, M.M. (1995) Production of biologically active hirudin in plant seeds using oleosin partitioning.  Plant Mol Biol 29: 1167-1180

Szarka SJ, Fitch M, Schaerer S and Moloney, M.M.  (1995) Classification and expression of a family of cyclin gene homologues in Brassica napus.  Plant Mol Biol 27: 263-275

van Rooijen GJH and Moloney, M.M. (1995) Plant seed oil-bodies as carriers for foreign proteins. Nature Biotechnology 13: 72-77

van Rooijen GJH and Moloney, M.M. (1995) Structural requirements of oleosin domains for subcellular  targeting to the oil body. Plant Physiology 109: 1353-1361

+ 35 additional papers between 1979 and 1995

Refereed Reviews or Book Chapters:

Moloney, MM  (2002)   Oleosin Partitioning Technology for Production of Recombinant Proteins in Oil Seeds    In Handbook of Industrial Cell Culture: Mammalian, Microbial, and Plant Cells  Eds. Vinci, Victor A., Parekh, Sarad R.  Humana Press p. 279 – 298. 

Moloney, MM  (2002)   Plant Molecular Farming:   Using Oleosin Partitioning Technology in Oilseeds   In Plants as Factories for Protein Production  Eds. Hood, E., Howard, J.  Kluwer Academic Publishers, Dordrecht, The Netherlands  p. 55 – 75.

Moloney, M.M. (2000) Molecular farming using seeds as hosts.  In Seed Technology (Eds Bewley D and Black M) Sheffield Academic Press. pp 226-253

Moloney, M.M. (1998) Oleosins as carriers for foreign protein in plant seeds. In Engineering crops for industrial end uses (Eds Shewry PR, Napier, JA, Davis P) Portland Press pp 47-54

Moloney, M.M. and Holbrook LA (1997) Subcellular targeting and purification of recombinant proteins in plant production systems. In Biotechnology and Genetic Engineering Reviews (Ed MP Tombs) pp 14: 321-336

Moloney, M.M., van Rooijen GJH (1996) Recombinant proteins via oleosin partitioning.  INFORM 7(1) 107-114

Parmenter DL, Boothe JG Moloney, M.M. (1996) Production and purification of recombinant hirudin from plant seeds.  In Transgenic plants: a production system for industrial and pharmaceutical proteins  (Eds Owen MRL, Pen J) John Wiley & Sons

Moloney, M.M. (1995) “Molecular farming” in plants: achievements and prospects. In Biotechnol & Biotechnol Equipment 9/1995/1 3-9

Patents: (Total of 43 US patents; >300 patents issued worldwide)

Maurice Moloney, Joseph Boothe, Richard Keon, Cory Nykiforuk, Gijs van Rooijen  US Patent 7,547,821 – “Methods for the production of insulin in plants”   Issued Jun 16, 2009

Maurice Moloney, Joenel Alcantara, Gijs van Rooijen US Patent 7,531,325 – “Method for cleavage of fusion proteins”   Issued May 12, 2009

Maurice Moloney, Joenel Alcantara, Gijs van Rooijen US Patent 7,501,265 – “Method for producing and cleaving a fusion protein with an N-terminal chymosin pro-peptide”  Issued March 10, 2009

Gijs van Rooijen, Richard Glenn Keon, Yin Shen, Joseph Boothe, Maurice Moloney US Patent 7,390,936 – “Commercial production of chymosin in plants”  Issued June 24, 2008

Maurice Moloney, Joseph Boothe, Gijs van Rooijen US Patent 7,332,587 – “Oil bodies and associated proteins as affinity matrices”  Issued February 19, 2008

Steven Szarka, Gijs van Rooijen, Maurice Moloney   US Patent 7,093,383 – “Methods for the production of multimeric immunoglobulin, and related compounds” Issued August 29, 2006

Maurice Moloney, Gijs van Rooijen  US Patent 7,091,401 – “Expression of epidermal growth factor in plant seeds” Issued August 15, 2006

Maurice Moloney, Joseph Boothe, Gijs van Rooijen  US Patent 6,924,363 - “Oil bodies and associated proteins as affinity matrices” Issued August 2, 2005

Deckers, H, van Rooijen, G, Boothe, J, Goll, J, Moloney, M.M., Schryvers, AB, Alcantara, J, Hutchins, WA  (2004)   Immunogenic Formulations Comprising Oil Bodies.  United States Patent No. 6,761,914, issued July 13, 2004.

Moloney, M.M., van Rooijen, G. (2004) Preparation of Heterologous Proteins on Oil Bodies.  United States Patent No. 6,753,167, issued June 22, 2004.

Moloney, M.M., Dalmia, BK (2004) Preparation of Thioredoxin and Thioredoxin Reductase Proteins on Oil Bodies.  United States Patent No. 6,750,046, issued June 15, 2004.

Peoples, OP, Moloney, M.M., Patterson, N, Snell, KD (2003) Modification of Fatty Acid Metabolism in Plants.  Publication No.  2003/0233677, published December 18, 2003.

Moloney, M.M., van Rooijen, G.  Expression of Epidermal Growth Factor in Plant Seeds.  Publication No. US 2003/0177537, published Sept. 18, 2003.

van Rooijen, G., Alcantera, J., Moloney, MM (2003) Method for cleavage of fusion proteins.  Publication No. US 2003/0166162, published September 4, 2003.

Deckers, HM, van Rooijen, G, Boothe, J, Goll, J, Moloney, MM (2003) Products for Topical Applications Comprising Oil Bodies.  United States Patent No.  6,599,513, issued July 29, 2003.

Deckers, HM, van Rooijen, G, Boothe, J, Goll, J, Moloney, MM (2003) Products for Topical Applications Comprising Oil Bodies.  United States Patent No. 6,596,287, issued July 22, 2003.

Moloney, M.M., van Rooijen, G, (2003)  Preparation of Heterologous Proteins on Oil Bodies.  United States Patent No. 6,753,167, issued June 22, 2004.

Peoples, OP, Moloney, M.M., Patterson, N, Snell, KD (2003) Modification of Fatty Acid Metabolism in Plants.  United States Patent No.  6,586,658,  issued July 1, 2003.

Deckers, HM, van Rooijen, G, Boothe, J, Goll, J, Moloney, MM (2003) Products for Topical Applications Comprising Oil Bodies.  United States Patent No.  6, 582, 710, issued June 24, 2003.

Moloney, M.M., Boothe, J, van Rooijen, G.  (2003) Oil Bodies and Associated Protein as Affinity Matrices.  Publication No. US 2003/0096320, published May 22, 2003.

Szarka, S, Moloney, MM (2003) Method for production of multimeric immunoglobulins and related compositions.  Publication No. US 2003/0093832, published May 15, 2003.

Moloney, M.M., Boothe, J, van Rooijen, G.  (2003) Oil Bodies and Associated Protein as Affinity Matrices.  Publication No. US 2003/0059910, published Mar. 27, 2003.

Moloney, M.M., Boothe,J., van Rooijen, G.  (2003) Oil Bodies and Associated Protein as Affinity Matrices.  United States Patent No. 6,509,453, issued January 21, 2003.

Deckers, HM, van Rooijen, G, Goll, J., Moloney, MM  (2002) Products for topical applications comprising oil bodies. United States Patent No. 6,372,234, issued April 16, 2002.

Deckers HM, van Rooijen G, Boothe J, Goll J, Mahmoud S, Moloney, M.M. (2001) Uses of Oil Bodies.  United States Patent No. 6,210,742, issued April 3, 2001.

Habibi H, Moloney, M.M. (2001) Expression of Somatotropin in Plant Seeds.  United States Patent No. 6,288,304, issued September 11, 2001.

Deckers HM, van Rooijen G, Boothe J, Goll J, and Moloney, M.M. (2001) Oil Body Based Personal Care Products.  United States Patent No. 6,183,762 B1, issued Feb. 6, 2001.

Deckers HM, van Rooijen G, Boothe J, Goll J, Mahmoud S and Moloney, M.M. (2000) Uses of Oil Bodies.  United States Patent No. 6,146,645, issued Nov. 14, 2000.

Cheng K-J, Selinger LB, Liu J-H, Hu Y, Forsberg CW and Moloney, M.M. (2000) Xylanase obtained from an anaerobic fungus.  United States Patent No. 6,137,032, issued Oct. 24, 2000

Cheng K-J, Selinger LB, Liu J-H, Hu Y, Forsberg CW and Moloney, M.M. (1999) Xylanase obtained from an anaerobic fungus.  United States Patent No. 5,948,667, issued Sept. 7, 1999.

Moloney, M.M., van Rooijen GJH, and Boothe J (1999) Oil bodies and associated proteins as affinity matrices.  United States Patent No. 5,856,452, issued Jan. 5, 1999

Moloney, M.M. (1999) Preparation of heterologous proteins on oil bodies.  United States Patent No. 5,948,682, issued Sept. 7, 1999.

Deckers HM, van Rooijen GJH, Boothe J, Goll J, Moloney, M.M. and Mahmoud S (1998) Uses of Oil bodies. PCT Patent Application WO 98/53698. Published 12/98

Moloney, M.M., Alcantara J and van Rooijen GJH (1998) Method for cleavage of fusion proteins. PCT Application WO 98/49326. Published 11/98

Moloney, MM (1998) Transformation and foreign gene expression in Brassica spp.  United States Patent No. 5,750,871, issued May 12, 1998.

Moloney, M.M., van Rooijen GJH, and Boothe J (1998) Oil bodies and associated proteins as affinity matrices.  PCT Application WO 98/27115.  Published 6/98

Moloney, M.M., Boothe J, and van Rooijen GJH (1996) Oil bodies and associated proteins as affinity matrices.  United States Patent No. 5,856,452, issued Jan. 5/99

Moloney, MM (1995) Transformation and foreign gene expression in Brassica spp.  United States Patent No. 5,463,174, issued Oct. 31, 1995.

Moloney, MM (1993) Transformation and foreign gene expression in Brassica spp.  United States Patent No. 5,188,958, issued Feb. 23, 1993.

Moloney, M.M. (1992) Oil body protein cis elements as regulatory signals for seed specific expression. This patent describes the cis-acting sequences of oleosin genes which may be used to drive seed specific expression in transgenic plants.  United States Patent No. 5,792,922, issued November 8, 1998

Moloney, M.M. (1991) Oil body proteins as carriers of high value proteins. This patent describes a novel procedure for the production of high value peptides such as pharmaceuticals, enzymes, peptide hormones and adhesives in oilseeds. The method provides for a unique purification process which renders economical the production of such proteins in plant seeds.  United States Patent No. 5,650,554, issued Jul 22/97

Hilliard J, Moloney, M.M. (1989) Probe for electrofusion, electroporation or like procedure II.  United States Patent No. 4,882,281, issued Nov. 21, 1989.  This patent describes a novel probe with multiple electrodes for the performance of electroporation / electrofusion experiments.  Permits the efficient transformation of bacterial or plant cells using a voltage generator of less than 600V.

Moloney, MM and Hilliard, J  (1986) A probe for electrofusion, electroporation or like procedure. US Patent No. 4,695,547. This patent describes a novel probe and set-up for the performance of electroporation/electrofusion experiments.  The patent has been licensed by Hoefer Scientific of San Fransisco CA and is the basis of their `Progenitor' series of electroporation devices.

Moloney, MM (1986) Transformation of Brassica spp using Agrobacterium vectors.  Applied U.S. Patent Office, May 1986. European claims accepted May 1987 #868,640. This patent describes a route to the production of transgenic Brassica plants using Agrobacterium vectors.  Claims involve several target tissues.  Issued March/92.